GABAA-rho receptor
| gamma-aminobutyric acid (GABA) receptor, rho 1 | |
|---|---|
| Identifiers | |
| Symbol | GABRR1 |
| Entrez | 2569 |
| HUGO | 4090 |
| OMIM | 137161 |
| RefSeq | NM_002042 |
| UniProt | P24046 |
| Other data | |
| Locus | Chr. 6 q14-q21 |
| gamma-aminobutyric acid (GABA) receptor, rho 2 | |
|---|---|
| Identifiers | |
| Symbol | GABRR2 |
| Entrez | 2570 |
| HUGO | 4091 |
| OMIM | 137162 |
| RefSeq | NM_002043 |
| UniProt | P28476 |
| Other data | |
| Locus | Chr. 6 q14-q21 |
| gamma-aminobutyric acid (GABA) receptor, rho 3 | |
|---|---|
| Identifiers | |
| Symbol | GABRR3 |
| Entrez | 200959 |
| HUGO | 17969 |
| RefSeq | NM_001105580 |
| UniProt | Q9UIV9 |
| Other data | |
| Locus | Chr. 3 q12.2 |
The GABAA-rho receptor (previously known as the GABAC receptor) is a subclass of GABAA receptors composed entirely of rho (ρ) subunits. GABAA receptors including those of the ρ-subclass are ligand-gated ion channels responsible for mediating the effects of gamma-amino butyric acid (GABA), the major inhibitory neurotransmitter in the brain. The GABAA-ρ receptor, like other GABAA receptors, is expressed in many areas of the brain, but in contrast to other GABAA receptors, the GABAA-ρ receptor has especially high expression in the retina.
A second type of ionotropic GABA receptor, insensitive to typical allosteric modulators of GABAA receptor channels such as benzodiazepines and barbiturates, was designated GABAС receptor. Native responses of the GABAC receptor type occur in retinal bipolar or horizontal cells across vertebrate species.
GABAС receptors are exclusively composed of ρ (rho) subunits that are related to GABAA receptor subunits. Although the term "GABAС receptor" is frequently used, GABAС may be viewed as a variant within the GABAA receptor family. Others have argued that the differences between GABAС and GABAA receptors are large enough to justify maintaining the distinction between these two subclasses of GABA receptors. However, since GABAС receptors are closely related in sequence, structure, and function to GABAA receptors and since other GABAA receptors besides those containing ρ subunits appear to exhibit GABAС pharmacology, the Nomenclature Committee of the IUPHAR has recommended that the GABAС term no longer be used and these ρ receptors should be designated as the ρ subfamily of the GABAA receptors (GABAA-ρ).
...
Wikipedia