G6PC3

G6PC3
Identifiers
Aliases	G6PC3, SCN4, UGRP, glucose 6 phosphatase catalytic subunit 3, glucose-6-phosphatase catalytic subunit 3
External IDs	MGI: 1915651 HomoloGene: 16304 GeneCards: G6PC3
Gene ontology Molecular function • hydrolase activity • glucose-6-phosphatase activity Cellular component • integral component of membrane • integral component of endoplasmic reticulum membrane • endoplasmic reticulum membrane • membrane • endoplasmic reticulum Biological process • phosphate-containing compound metabolic process • gluconeogenesis • glucose 6-phosphate metabolic process • glucose transport • glucose-6-phosphate transport • dephosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	92579	68401
Ensembl	ENSG00000141349	ENSMUSG00000034793
UniProt	Q9BUM1	Q6NSQ9
RefSeq (mRNA)	NM_138387 NM_001319945	NM_175935
RefSeq (protein)	NP_001306874 NP_612396	NP_787949.2 NP_787949
Location (UCSC)	Chr 17: 44.07 – 44.08 Mb	Chr 11: 102.19 – 102.19 Mb
PubMed search

92579

68401

ENSG00000141349

ENSMUSG00000034793

Q9BUM1

Q6NSQ9

NM_138387
NM_001319945

NM_175935

NP_001306874
NP_612396

NP_787949.2
NP_787949

Glucose-6-phosphatase 3, also known as glucose-6-phosphatase beta, is an enzyme that in humans is encoded by the G6PC3 gene.

This gene encodes the catalytic subunit of glucose 6-phosphatase (G6Pase). G6Pase is located in the endoplasmic reticulum (ER) and catalyzes the hydrolysis of glucose 6-phosphate to glucose and phosphate in the last step of the gluconeogenic and glycogenolytic pathways.

Mutations in this gene result in autosomal recessive severe congenital neutropenia.

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Wikipedia