G6PC2

G6PC2
Identifiers
Aliases	G6PC2, IGRP, glucose-6-phosphatase catalytic subunit 2
External IDs	MGI: 1277193 HomoloGene: 41423 GeneCards: G6PC2
Genetically Related Diseases
disease of metabolism
Gene ontology Molecular function • hydrolase activity • glucose-6-phosphatase activity Cellular component • membrane • integral component of membrane • integral component of endoplasmic reticulum membrane • endoplasmic reticulum membrane • endoplasmic reticulum Biological process • gluconeogenesis • glucose 6-phosphate metabolic process • glucose homeostasis • glucose transport • regulation of insulin secretion • dephosphorylation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	57818	14378
Ensembl	n/a	ENSMUSG00000005232
UniProt	Q9NQR9	Q9Z186
RefSeq (mRNA)	NM_001081686 NM_021176	NM_001289856 NM_001289857 NM_021331
RefSeq (protein)	NP_001075155 NP_066999	NP_001276785.1 NP_001276786.1 NP_067306.1 NP_001276785 NP_001276786 NP_067306
Location (UCSC)	Chr 2: 168.9 – 168.91 Mb	Chr 2: 69.21 – 69.23 Mb
PubMed search

57818

14378

n/a

ENSMUSG00000005232

Q9NQR9

Q9Z186

NM_001081686
NM_021176

NM_001289856
NM_001289857
NM_021331

NP_001075155
NP_066999

NP_067306

Glucose-6-phosphatase 2 is an enzyme that in humans is encoded by the G6PC2 gene.

This gene encodes an enzyme belonging to the glucose-6-phosphatase catalytic subunit family. These enzymes are part of a multicomponent integral membrane system that catalyzes the hydrolysis of glucose-6-phosphate, the terminal step in gluconeogenic and glycogenolytic pathways, allowing the release of glucose into the bloodstream. The family member encoded by this gene is found in pancreatic islets and does not exhibit phosphohydrolase activity, but it is a major target of cell-mediated autoimmunity in diabetes. Several alternatively spliced transcript variants of this gene have been described, but their biological validity has not been determined.

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