G6PC

G6PC
Identifiers
Aliases	G6PC, G6PC1, G6PT, GSD1, GSD1a, G6Pase, glucose-6-phosphatase catalytic subunit
External IDs	MGI: 95607 HomoloGene: 20079 GeneCards: G6PC
Gene ontology Molecular function • phosphate ion binding • phosphotransferase activity, alcohol group as acceptor • hydrolase activity • glucose-6-phosphatase activity Cellular component • integral component of membrane • endoplasmic reticulum membrane • membrane • intracellular membrane-bounded organelle • integral component of endoplasmic reticulum membrane • endoplasmic reticulum Biological process • gluconeogenesis • phosphorylated carbohydrate dephosphorylation • steroid metabolic process • glucose homeostasis • multicellular organism growth • glycogen catabolic process • urate metabolic process • lipid homeostasis • glycogen metabolic process • regulation of gene expression • response to food • phosphate-containing compound metabolic process • cholesterol homeostasis • glucose 6-phosphate metabolic process • triglyceride metabolic process • glucose transport • glucose-6-phosphate transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2538	14377
Ensembl	ENSG00000131482	ENSMUSG00000078650
UniProt	P35575	P35576
RefSeq (mRNA)	NM_001270397 NM_000151	NM_008061
RefSeq (protein)	NP_000142 NP_001257326	NP_032087.2 NP_032087
Location (UCSC)	Chr 17: 42.9 – 42.91 Mb	Chr 11: 101.37 – 101.38 Mb
PubMed search

2538

14377

ENSG00000131482

ENSMUSG00000078650

P35575

P35576

NM_001270397
NM_000151

NM_008061

NP_000142
NP_001257326

NP_032087.2
NP_032087

Glucose-6-phosphatase, catalytic subunit (glucose 6-phosphatase alpha) is an enzyme that in humans is encoded by the G6PC gene.

Glucose-6-phosphatase is an integral membrane protein of the endoplasmic reticulum that catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate. It is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Defects in the enzyme cause glycogen storage disease type I (von Gierke disease).

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Wikipedia