G3BP1

G3BP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3Q90, 4FCJ, 4FCM, 4IIA
Identifiers
Aliases	G3BP1, G3BP, HDH-VIII, G3BP stress granule assembly factor 1
External IDs	MGI: 1351465 HomoloGene: 38096 GeneCards: G3BP1
Gene ontology Molecular function • DNA binding • nucleotide binding • ATP-dependent RNA helicase activity • helicase activity • ATP-dependent DNA helicase activity • protein binding • nucleic acid binding • nuclease activity • endonuclease activity • ATP binding • hydrolase activity • mRNA binding • RNA binding Cellular component • membrane • focal adhesion • plasma membrane • intracellular • cytoplasmic stress granule • nucleus • cytoplasm • cytosol • intracellular ribonucleoprotein complex Biological process • nucleic acid phosphodiester bond hydrolysis • transport • Ras protein signal transduction • negative regulation of canonical Wnt signaling pathway • DNA duplex unwinding Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10146	27041
Ensembl	ENSG00000145907	ENSMUSG00000018583
UniProt	Q13283	P97855
RefSeq (mRNA)	NM_005754 NM_198395	NM_013716
RefSeq (protein)	NP_005745 NP_938405	NP_038744.1 NP_038744
Location (UCSC)	Chr 5: 151.77 – 151.81 Mb	Chr 11: 55.47 – 55.5 Mb
PubMed search

3Q90, 4FCJ, 4FCM, 4IIA

10146

27041

ENSG00000145907

ENSMUSG00000018583

Q13283

P97855

NM_005754
NM_198395

NM_013716

NP_005745
NP_938405

NP_038744.1
NP_038744

Ras GTPase-activating protein-binding protein 1 is an enzyme that in humans is encoded by the G3BP1 gene.

This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It was originally reported to bind specifically to the Ras-GTPase-activating protein by associating with its SH3 domain, but this interaction has recently been challenged. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

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