Takatsukasa Kanehira (鷹司 兼平?, 1228 – 1294), fourth son of Konoe Iezane, was a court noble (kugyo) of the Kamakura period of Japan, and founding father of the Takatsukasa family. His sons include Kanetada and Mototada.
After holding some high-ranking positions in the court, in 1252 he was appointed Sessho and became the head of the Fujiwara clan. In 1254 he was appointed Kampaku. In 1290 he retired and became a priest. He was also known as a calligrapher.