Fucosyltransferase 3

FUT3

Identifiers

FUT3, CD174, FT3B, FucT-III, LE, Les, Fucosyltransferase 3, fucosyltransferase 3 (Lewis blood group)

External IDs

Gene ontology
Molecular function	• transferase activity • alpha-(1->3)-fucosyltransferase activity • fucosyltransferase activity • transferase activity, transferring glycosyl groups • 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity
Cellular component	• integral component of membrane • Golgi cisterna membrane • Golgi apparatus • extracellular exosome • membrane • Golgi membrane
Biological process	• cell-cell recognition • oligosaccharide biosynthetic process • protein glycosylation • macromolecule glycosylation • fucosylation
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


2525


n/a

Ensembl


ENSG00000171124


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UniProt


P21217


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RefSeq (mRNA)


NM_000149 NM_001097639 NM_001097640 NM_001097641


n/a

RefSeq (protein)


NP_000140 NP_001091108 NP_001091109 NP_001091110


n/a

Location (UCSC)

Chr 19: 5.84 – 5.85 Mb

n/a

PubMed search

n/a

2525

n/a

ENSG00000171124

n/a

P21217

n/a

NM_000149
NM_001097639
NM_001097640
NM_001097641

n/a

NP_000140
NP_001091108
NP_001091109
NP_001091110

n/a

Galactoside 3(4)-L-fucosyltransferase is an enzyme that in humans is encoded by the FUT3 gene.

The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.

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Wikipedia