Fructose carrier

SLC2A5

Identifiers

SLC2A5, GLUT-5, GLUT5, solute carrier family 2 member 5

External IDs

MGI: 1928369 HomoloGene: 74459 GeneCards: SLC2A5

Gene ontology
Molecular function	• substrate-specific transmembrane transporter activity • transmembrane transporter activity • transporter activity • fructose binding • fructose transmembrane transporter activity • glucose transmembrane transporter activity
Cellular component	• integral component of membrane • membrane • plasma membrane • integral component of plasma membrane • apical plasma membrane • sarcolemma • extracellular exosome • specific granule membrane
Biological process	• hexose transport • carbohydrate metabolic process • cellular response to fructose stimulus • transport • fructose transport • glucose transport • carbohydrate transport • fructose import across plasma membrane • response to fructose • transmembrane transport • glucose transmembrane transport • regulation of systemic arterial blood pressure mediated by a chemical signal • neutrophil degranulation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


6518


56485

Ensembl


ENSG00000142583


ENSMUSG00000028976

UniProt


P22732


Q9WV38

RefSeq (mRNA)


NM_001135585 NM_003039 NM_001328619 NM_001328620 NM_001328621


NM_019741

RefSeq (protein)


NP_001129057 NP_001315548 NP_001315549 NP_001315550 NP_003030


NP_062715.2 NP_062715

Location (UCSC)

Chr 1: 9.04 – 9.09 Mb

Chr 4: 150.12 – 150.14 Mb

PubMed search

NM_001135585
NM_003039
NM_001328619
NM_001328620
NM_001328621

NM_019741

NP_001129057
NP_001315548
NP_001315549
NP_001315550
NP_003030

NP_062715.2
NP_062715

GLUT5 is a fructose transporter expressed on the apical border of enterocytes in the small intestine. GLUT5 allows for fructose to be transported from the intestinal lumen into the enterocyte by facilitated diffusion due to fructose's high concentration in the intestinal lumen. GLUT5 is also expressed in skeletal muscle, testis, kidney, fat tissue (adipocytes), and brain.

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