Fructosamine-3-kinase

FN3K
Identifiers
Aliases	FN3K, fructosamine 3 kinase
External IDs	MGI: 1926834 HomoloGene: 23336 GeneCards: FN3K
Gene location (Human) Chr. Chromosome 17 (human) Band 17q25.3 Start 82,735,575 bp End 82,751,197 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band n/a Start 121,434,913 bp End 121,450,491 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • fructosamine-3-kinase activity • kinase activity Cellular component • cytosol Biological process • post-translational protein modification • epithelial cell differentiation • fructoselysine metabolic process • phosphorylation • fructosamine metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	64122	63828
Ensembl	ENSG00000167363	ENSMUSG00000025175
UniProt	Q9H479	Q9ER35
RefSeq (mRNA)	NM_022158	NM_001038699 NM_022014
RefSeq (protein)	NP_071441	NP_001033788 NP_071297
Location (UCSC)	Chr 17: 82.74 – 82.75 Mb	Chr 17: 121.43 – 121.45 Mb
PubMed search

64122

63828

ENSG00000167363

ENSMUSG00000025175

Q9H479

Q9ER35

NM_022158

NM_001038699
NM_022014

NP_071441

NP_001033788
NP_071297

Fructosamine-3-kinase is an enzyme that in humans is encoded by the FN3K gene.

FN3K catalyzes phosphorylation of fructosamines formed by glycation, the nonenzymatic reaction of glucose with primary amines followed by Amadori rearrangement. Phosphorylation of fructosamines may initiate metabolism of the modified amine and result in deglycation of glycated proteins.

FN3K is responsible for the formation of fructose 3-phosphate (F3P), a compound identified in the lenses of diabetic rats. The spontaneous decomposition of F3P leads to the formation of 3-deoxyglucosone (3DG). 3DG contributes to diabetic complications. Treatment of normal and diabetic rats with an inhibitor of FN3K demonstrated a large reduction (~50%) in systemic 3DG in both groups. Removal of 3DG at its source by inhibition of FN3K is a viable option to treat diabetes related diseases since it would require a much smaller dose of drug.

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Wikipedia