The French colonization of Texas began with Fort Saint Louis in present-day southeastern Texas. It was established in 1685 near Arenosa Creek and Matagorda Bay by explorer Robert Cavelier de La Salle. He intended to found the colony at the mouth of the Mississippi River, but inaccurate maps and navigational errors caused his ships to anchor instead 400 miles (640 km) to the west, off the coast of Texas. The colony survived until 1688. The present-day town of Inez is near the fort's site.
The colony faced numerous difficulties during its brief existence, including Native American raids, epidemics, and harsh conditions. From that base, La Salle led several expeditions to find the Mississippi River. These did not succeed, but La Salle did explore much of the Rio Grande and parts of east Texas.
During one of his absences in 1686, the colony's last ship was wrecked, leaving the colonists unable to obtain resources from the French colonies of the Caribbean. As conditions deteriorated, La Salle realized the colony could survive only with help from the French settlements in Illinois Country to the north, along the Mississippi and Illinois Rivers. His last expedition ended along the Brazos River in early 1687, when La Salle and five of his men were murdered during a mutiny.
Although a handful of men reached Illinois Country, help never made it to Fort St. Louis. Most of the remaining members of the colony were killed during a Karankawa raid in late 1688, four children survived after being adopted as captives. Although the colony lasted only three years, it established France's claim to possession of the region that is now Texas. The United States later claimed, unsuccessfully, this region as part of the Louisiana Purchase because of the early French colony.