Frataxin

FXN

Protein FXN PDB 1ekg.png

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1EKG, 1LY7, 3S4M, 3S5D, 3S5E, 3S5F, 3T3J, 3T3K, 3T3L, 3T3T, 3T3X

Identifiers

FXN, CyaY, FA, FARR, FRDA, X25, frataxin

External IDs

OMIM: 606829 MGI: 1096879 HomoloGene: 47908 GeneCards: FXN

Gene ontology
Molecular function	• protein binding • iron chaperone activity • 2 iron, 2 sulfur cluster binding • oxidoreductase activity • iron-sulfur cluster binding • ferrous iron binding • metal ion binding • ferric iron binding • ferroxidase activity
Cellular component	• cytoplasm • cytosol • mitochondrial matrix • mitochondrion
Biological process	• transport • regulation of ferrochelatase activity • positive regulation of cell proliferation • response to iron ion • iron-sulfur cluster assembly • ion transport • positive regulation of aconitate hydratase activity • negative regulation of multicellular organism growth • aerobic respiration • oxidative phosphorylation • negative regulation of organ growth • positive regulation of cell growth • mitochondrion organization • cellular response to hydrogen peroxide • embryo development ending in birth or egg hatching • negative regulation of release of cytochrome c from mitochondria • positive regulation of succinate dehydrogenase activity • protein autoprocessing • negative regulation of apoptotic process • adult walking behavior • proprioception • small molecule metabolic process • iron ion homeostasis • oxidation-reduction process • iron incorporation into metallo-sulfur cluster • cellular iron ion homeostasis • heme biosynthetic process • positive regulation of lyase activity • positive regulation of catalytic activity
Sources:Amigo / QuickGO

RNA expression pattern

PBB GE FXN 205565 s at tn.png

More reference expression data

Orthologs

Species

Human

Mouse


2395


14297


ENSG00000165060


ENSMUSG00000059363


Q16595


O35943

RefSeq (mRNA)


NM_181425 NM_000144 NM_001161706


NM_008044

RefSeq (protein)


NP_000135 NP_001155178 NP_852090


NP_032070.1

Location (UCSC)

Chr 9: 69.04 – 69.1 Mb

Chr 19: 24.26 – 24.28 Mb

PubMed search

1EKG, 1LY7, 3S4M, 3S5D, 3S5E, 3S5F, 3T3J, 3T3K, 3T3L, 3T3T, 3T3X

ENSG00000165060

ENSMUSG00000059363

NM_181425
NM_000144
NM_001161706

NP_000135
NP_001155178
NP_852090

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Wikipedia

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