František Antonín Nickerl (December 4, 1813 in Prague – February 4, 1871 in Prague) was a Czech entomologist who specialised in Lepidoptera, especially those of the Riesengebirges.
František Nickerl was a professor of zoology in Graz and of natural history in Prague where he was also "Prof. Dr." of medicine. He was at some time a research worker and curator at the National Museum in Prague.That institution conserves his insect collection. He is not to be confused with Otokar Nickerl (1838–1920) also an entomologist.