Francis Scott, 2nd Duke of Buccleuch KT FRS (11 January 1695 – 22 April 1751) was a Scottish nobleman.
Buccleuch was the son of Sir James Scott, Earl of Dalkeith (son of James Scott, 1st Duke of Monmouth and Anne Scott, 1st Duchess of Buccleuch) and Lady Henrietta Hyde, daughter of Laurence Hyde, 1st Earl of Rochester. He was baptised on 20 January 1695 in St. James's Church, Westminster.
Following the death of his father in 1705, he was styled the Earl of Dalkeith, until he succeeded to the dukedom of Buccleuch, 6 February 1732, on the death of his grandmother, who was Duchess of Buccleuch in her own right. At the same time, other titles in the Scottish peerage came his way: Earl of Dalkeith and Baron Scott of Whitchester and Eskdale.
His grandfather, the Duke of Monmouth, was the illegitimate son of Charles II who raised a rebellion upon James II and VII's accession to the English, Scottish and Irish thrones, and was beheaded for it. Monmouth's noble titles were consequently forfeit; but in March 1743 two of those titles were restored to his progeny when the House of Lords passed a bill making Buccleuch the 2nd Earl of Doncaster, as well as 2nd Baron Scott of Tindall, both in the English peerage (conferred 22 March 1743).
In his youth he attended Eton College. Throughout his adult life Buccleuch associated himself with institutions that promoted learning. He was a freemason, member of the Grand Lodge at a period when scientific interests figured prominently in its pursuits. From 24 June 1723 to 24 June 1724 he held the office of Grand Master of Freemasons. He was invested as a Fellow of the Royal Society (FRS) on 12 March 1724. He was closely associated with the Spalding Gentlemen's Society, a learned society of antiquaries, and he was the first to hold its office of Patron, inaugurated in 1734. On 18 April 1745 he was awarded the honorary degree of Doctor of the Civil Law by Oxford University.