Follistatin

FST
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3HH2, 2B0U, 2P6A
Identifiers
Aliases	FST, FS, follistatin
External IDs	OMIM: 136470 MGI: 95586 HomoloGene: 7324 GeneCards: FST
Gene ontology Molecular function • heparan sulfate proteoglycan binding • protein binding • signal transducer activity • activin binding Cellular component • extracellular region Biological process • positive regulation of hair follicle development • negative regulation of activin receptor signaling pathway • negative regulation of transcription from RNA polymerase II promoter • hematopoietic progenitor cell differentiation • signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10468	14313
Ensembl	ENSG00000134363	ENSMUSG00000021765
UniProt	P19883	P47931
RefSeq (mRNA)	NM_006350 NM_013409	NM_008046 NM_001301373 NM_001301375
RefSeq (protein)	NP_006341 NP_037541	NP_001288302.1 NP_001288304.1 NP_032072.1 NP_001288302 NP_001288304 NP_032072
Location (UCSC)	Chr 5: 53.48 – 53.49 Mb	Chr 13: 114.45 – 114.46 Mb
PubMed search

3HH2, 2B0U, 2P6A

10468

14313

ENSG00000134363

ENSMUSG00000021765

P19883

P47931

NM_006350
NM_013409

NM_008046
NM_001301373
NM_001301375

NP_006341
NP_037541

NP_032072

Follistatin also known as activin-binding protein is a protein that in humans is encoded by the FST gene. Follistatin is an glycoprotein that is expressed in nearly all tissues of higher animals.

Its primary function is the binding and bioneutralization of members of the TGF-β superfamily, with a particular focus on activin, a paracrine hormone.

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Wikipedia