Filamin A

FLNA

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2AAV, 2BP3, 2BRQ, 2J3S, 2JF1, 2K3T, 2K7P, 2MTP, 2W0P, 2WFN, 3CNK, 3HOC, 3HOP, 3HOR, 3ISW, 3RGH, 4M9P, 4P3W

Identifiers

Aliases

FLNA, ABP-280, ABPX, CSBS, CVD1, FLN, FLN-A, FLN1, FMD, MNS, NHBP, OPD, OPD1, OPD2, XLVD, XMVD, filamin A

External IDs

MGI: 95556 HomoloGene: 1119 GeneCards: FLNA

Gene location (Human)

Chr.	X chromosome (human)

Band	n/a	Start	154,348,524 bp
Band	n/a	End	154,374,638 bp

Gene location (Mouse)

Chr.	X chromosome (mouse)

Band	n/a	Start	74,223,461 bp
Band	n/a	End	74,249,820 bp

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• Rac GTPase binding • Ral GTPase binding • protein homodimerization activity • protein complex binding • transcription factor binding • mu-type opioid receptor binding • signal transducer activity • actin filament binding • small GTPase binding • kinase binding • Rho GTPase binding • actin binding • SMAD binding • Fc-gamma receptor I complex binding • G-protein coupled receptor binding • GTPase binding • RNA binding • potassium channel regulator activity • ion channel binding • cadherin binding • protein binding
Cellular component	• cytoplasm • membrane • focal adhesion • cortical cytoskeleton • plasma • Myb complex • dendritic shaft • protein complex • extracellular region • neuronal cell body • cell cortex • nucleolus • actin filament • actin cytoskeleton • perinuclear region of cytoplasm • extracellular exosome • cytoskeleton • nucleus • apical dendrite • filamentous actin • extracellular matrix • cell-cell junction • cytosol • Z disc
Biological process	• actin cytoskeleton reorganization • negative regulation of transcription from RNA polymerase I promoter • negative regulation of protein catabolic process • establishment of protein localization • protein stabilization • platelet degranulation • mRNA transcription from RNA polymerase II promoter • negative regulation of apoptotic process • receptor clustering • negative regulation of sequence-specific DNA binding transcription factor activity • cytoplasmic sequestering of protein • positive regulation of transcription factor import into nucleus • platelet activation • mitotic spindle assembly • positive regulation of substrate adhesion-dependent cell spreading • protein localization to cell surface • cell projection organization • adenylate cyclase-inhibiting dopamine receptor signaling pathway • actin crosslink formation • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of integrin-mediated signaling pathway • platelet aggregation • cell junction assembly • regulation of cell migration • wound healing, spreading of cells • semaphorin-plexin signaling pathway • formation of radial glial scaffolds • cerebral cortex development • cilium morphogenesis • protein localization to plasma membrane • positive regulation of potassium ion transmembrane transport • regulation of membrane repolarization during atrial cardiac muscle cell action potential • regulation of membrane repolarization during cardiac muscle cell action potential • positive regulation of neural precursor cell proliferation • positive regulation of neuron migration
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


2316


192176

Ensembl


ENSG00000196924


ENSMUSG00000031328

UniProt


P21333


Q8BTM8

RefSeq (mRNA)


NM_001110556 NM_001456


NM_001290421 NM_010227

RefSeq (protein)


NP_001104026 NP_001447


NP_001277350 NP_034357

Location (UCSC)

Chr X: 154.35 – 154.37 Mb

Chr X: 74.22 – 74.25 Mb

PubMed search

2AAV, 2BP3, 2BRQ, 2J3S, 2JF1, 2K3T, 2K7P, 2MTP, 2W0P, 2WFN, 3CNK, 3HOC, 3HOP, 3HOR, 3ISW, 3RGH, 4M9P, 4P3W

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