Filaggrin

FLG
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4PCW
Identifiers
Aliases	FLG, ATOD2, filaggrin
External IDs	HomoloGene: 136751 GeneCards: FLG
Gene ontology Molecular function • calcium ion binding • protein binding • structural molecule activity • metal ion binding • transition metal ion binding Cellular component • intermediate filament • keratohyalin granule • intracellular membrane-bounded organelle • nucleus • cytosol Biological process • multicellular organism development • keratinocyte differentiation • establishment of skin barrier • cornification Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2312	n/a
Ensembl	ENSG00000143631	n/a
UniProt	P20930	n/a
RefSeq (mRNA)	NM_002016	n/a
RefSeq (protein)	NP_002007	n/a
Location (UCSC)	Chr 1: 152.3 – 152.33 Mb	n/a
PubMed search		n/a

4PCW

2312

n/a

ENSG00000143631

n/a

P20930

n/a

NM_002016

n/a

NP_002007

n/a

Filaggrin (filament aggregating protein) is a filament-associated protein that binds to keratin fibers in epithelial cells. Ten to twelve filaggrin units are post-translationally hydrolized from a large profilaggrin precursor protein during terminal differentiation of epidermal cells. In humans, profilaggrin is encoded by the FLG gene, which is part of the S100 fused-type protein (SFTP) family within the epidermal differentiation complex on chromosome 1q21.

Filaggrin monomers are tandemly clustered into a large, 350kDa protein precursor known as profilaggrin. In the epidermis, these structures are present in the keratohyalin granules in cells of the stratum granulosum. Profilaggrin undergoes proteolytic processing to yield individual filaggrin monomers at the transition between the stratum granulosum and the stratum corneum, which may be facilitated by calcium-dependent enzymes.

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