Fibroblast growth factor 8

FGF8

Protein FGF8 PDB 2fdb.png

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2FDB

Identifiers

FGF8, AIGF, FGF-8, HBGF-8, HH6, KAL6, fibroblast growth factor 8

External IDs

MGI: 99604 HomoloGene: 7715 GeneCards: FGF8

Gene location (Human)

Chr.	Chromosome 10 (human)

Band	No data available	Start	101,770,130 bp
Band	No data available	End	101,780,369 bp

Gene location (Mouse)

Chr.	Chromosome 19 (mouse)

Band	No data available	Start	45,736,798 bp
Band	No data available	End	45,742,915 bp

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• type 1 fibroblast growth factor receptor binding • type 2 fibroblast growth factor receptor binding • growth factor activity • fibroblast growth factor receptor binding • chemoattractant activity • protein tyrosine kinase activity • 1-phosphatidylinositol-3-kinase activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • Ras guanyl-nucleotide exchange factor activity
Cellular component	• extracellular region • intracellular • external side of plasma membrane • extracellular space
Biological process	• negative regulation of neuron apoptotic process • cell migration involved in mesendoderm migration • male genitalia development • epithelial to mesenchymal transition involved in endocardial cushion formation • outflow tract morphogenesis • embryonic heart tube development • mesonephros development • heart looping • forebrain neuron development • blood vessel remodeling • central nervous system neuron development • positive regulation of ERK1 and ERK2 cascade • metanephros development • cell proliferation in forebrain • positive regulation of mitotic nuclear division • gonad development • pharyngeal system development • branching involved in salivary gland morphogenesis • apoptotic process • dopaminergic neuron differentiation • cell fate commitment • limb morphogenesis • kidney development • lung development • anatomical structure morphogenesis • signal transduction involved in regulation of gene expression • regulation of odontogenesis of dentin-containing tooth • response to oxidative stress • embryo development ending in birth or egg hatching • forebrain morphogenesis • heart development • telencephalon development • branching involved in ureteric bud morphogenesis • midbrain-hindbrain boundary development • branching involved in blood vessel morphogenesis • thyroid-stimulating hormone-secreting cell differentiation • positive chemotaxis • mesodermal cell migration • cell differentiation • dorsal/ventral axon guidance • corticotropin hormone secreting cell differentiation • organ induction • neural plate morphogenesis • positive regulation of organ growth • negative regulation of apoptotic process • BMP signaling pathway • outflow tract septum morphogenesis • odontogenesis • thyroid gland development • pallium development • gastrulation • canonical Wnt signaling pathway • phosphatidylinositol-mediated signaling • subpallium development • lung morphogenesis • response to organic cyclic compound • otic vesicle formation • forebrain dorsal/ventral pattern formation • heart morphogenesis • aorta morphogenesis • generation of neurons • MAPK cascade • neuroepithelial cell differentiation • multicellular organism development • fibroblast growth factor receptor signaling pathway • positive regulation of gene expression • negative regulation of cardiac muscle tissue development • determination of left/right symmetry • inner ear morphogenesis • positive regulation of cell proliferation • bone development • motor neuron axon guidance • positive regulation of cell division • response to drug • embryonic hindlimb morphogenesis • positive regulation of GTPase activity • phosphatidylinositol phosphorylation • phosphatidylinositol-3-phosphate biosynthetic process • peptidyl-tyrosine phosphorylation • regulation of phosphatidylinositol 3-kinase signaling • positive regulation of cell differentiation • interleukin-7-mediated signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


2253


14179


ENSG00000107831


ENSMUSG00000025219


P55075


P37237

RefSeq (mRNA)


NM_001206389 NM_006119 NM_033163 NM_033164 NM_033165


NM_001166361 NM_001166362 NM_001166363 NM_010205

RefSeq (protein)


NP_001193318 NP_006110 NP_149353 NP_149354 NP_149355


NP_001159833 NP_001159834 NP_001159835 NP_034335

Location (UCSC)

Chr 10: 101.77 – 101.78 Mb

Chr 19: 45.74 – 45.74 Mb

PubMed search

ENSG00000107831

ENSMUSG00000025219

NM_001206389
NM_006119
NM_033163
NM_033164
NM_033165

NM_001166361
NM_001166362
NM_001166363
NM_010205

NP_001193318
NP_006110
NP_149353
NP_149354
NP_149355

...
Wikipedia

...