Ferroportin

SLC40A1
Identifiers
Aliases	SLC40A1, FPN1, HFE4, IREG1, MST079, MSTP079, MTP1, SLC11A3, solute carrier family 40 member 1
External IDs	OMIM: 604653 MGI: 1315204 HomoloGene: 40959 GeneCards: SLC40A1
Gene ontology Molecular function • ferrous iron transmembrane transporter activity • iron ion transmembrane transporter activity • iron channel activity • peptide hormone binding • protein binding • receptor activity Cellular component • cytoplasm • integral component of membrane • membrane • synaptic vesicle • plasma membrane • integral component of plasma membrane • intracellular • basolateral plasma membrane • nucleoplasm • cytosol Biological process • iron ion transmembrane transport • lymphocyte homeostasis • spleen trabecula formation • iron ion homeostasis • negative regulation of apoptotic process • ion transport • spleen development • multicellular organismal iron ion homeostasis • iron ion transport • endothelium development • transport • ferrous iron export across plasma membrane • positive regulation of transcription from RNA polymerase II promoter • cellular iron ion homeostasis • regulation of transcription from RNA polymerase II promoter in response to iron Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	30061	53945
Ensembl	ENSG00000138449	ENSMUSG00000025993
UniProt	Q9NP59	Q9JHI9
RefSeq (mRNA)	NM_014585	NM_016917
RefSeq (protein)	NP_055400	NP_058613.2 NP_058613
Location (UCSC)	Chr 2: 189.56 – 189.58 Mb	Chr 1: 45.91 – 45.93 Mb
PubMed search

30061

53945

ENSG00000138449

ENSMUSG00000025993

Q9NP59

Q9JHI9

NM_014585

NM_016917

NP_055400

NP_058613.2
NP_058613

Ferroportin-1, also known as solute carrier family 40 member 1 (SLC40A1) or iron-regulated transporter 1 (IREG1), is a protein that in humans is encoded by the SLC40A1 gene, and is part of the Ferroportin (Fpn) Family (TC# 2.A.100). Ferroportin is a transmembrane protein that transports iron from the inside of a cell to the outside of the cell. After iron is absorbed into the cells of the intestine, ferroportin allows that iron to be transported out of those cells and into the bloodstream.

Members of the FPN family consist of 400-800 amino acid residues, with a highly conserved histidine at residue position 32 (H32), and exhibit 8-11 putative transmembrane segments (TMSs). When H32 is mutated, lower activity in its iron transport role is observed. Ferroportin can also function as a manganese exporter. Because ferroportin extrudes Fe²⁺ from the cell, ferroportin is presumed to function by cation (H⁺ or Na⁺) antiport.

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Wikipedia