Ferritin light chain

FTL
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2FFX, 2FG4, 2FG8, 3KXU
Identifiers
Aliases	FTL, LFTD, NBIA3, ferritin, light polypeptide, ferritin light chain
External IDs	MGI: 5434102 HomoloGene: 79330 GeneCards: FTL
Gene ontology Molecular function • iron ion binding • protein binding • ferric iron binding • metal ion binding • identical protein binding Cellular component • cytosol • extracellular exosome • intracellular ferritin complex • membrane • extracellular region • azurophil granule lumen • autolysosome Biological process • iron ion homeostasis • iron ion transport • cellular iron ion homeostasis • intracellular sequestering of iron ion • neutrophil degranulation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2512	434624
Ensembl	ENSG00000087086	n/a
UniProt	P02792	n/a
RefSeq (mRNA)	NM_000146	XM_003688879 XM_006542883
RefSeq (protein)	NP_000137	n/a
Location (UCSC)	Chr 19: 48.97 – 48.97 Mb	n/a
PubMed search

2FFX, 2FG4, 2FG8, 3KXU

2512

434624

ENSG00000087086

n/a

P02792

n/a

NM_000146

XM_003688879
XM_006542883

NP_000137

n/a

Ferritin light chain is a protein that in humans is encoded by the FTL gene.

It is abnormally expressed in fetuses of both IVF and ICSI, which may contribute to the increase risk of birth defects in these ART.

This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. This gene has multiple pseudogenes.

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