Femring

Estradiol acetate

Clinical data
Pronunciation	/ˌɛstrəˈdaɪoʊl ˈæsəteɪt/ ES-trə-DYE-ohl ASS-ə-tayt
Trade names	Femtrace, Femring, Menoring
Synonyms	E2A; E3A; Estradiol 3-acetate
Routes of administration	By mouth, vaginal (ring)
Drug class	Estrogen; Estrogen ester
ATC code	G03CA03 (WHO)
Legal status
Legal status	In general: ℞ (Prescription only)
Identifiers
IUPAC name [(8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] acetate
CAS Number	4245-41-4
PubChem CID	9818306
DrugBank	DBSALT000065
ChemSpider	7994056
UNII	5R97F5H93P
KEGG	D04061
ChEMBL	CHEMBL1200430
ECHA InfoCard	100.110.039
Chemical and physical data
Formula	C20H26O3
Molar mass	314.419 g/mol
3D model (JSmol)	Interactive image
SMILES C(C)(=O)Oc1ccc2[C@@H]3CC[C@@]4([C@H](CC[C@@H]4[C@@H]3CCc2c1)O)C
InChI InChI=1S/C20H26O3/c1-12(21)23-14-4-6-15-13(11-14)3-5-17-16(15)9-10-20(2)18(17)7-8-19(20)22/h4,6,11,16-19,22H,3,5,7-10H2,1-2H3/t16-,17-,18+,19+,20+/m1/s1 Key:FHXBMXJMKMWVRG-SLHNCBLASA-N

Estradiol acetate, sold under the brand names Femtrace, Femring, and Menoring, is an estrogen medication which is used as a part of hormone therapy for the treatment of menopausal symptoms in the United States, Europe, and elsewhere throughout the world. It is a synthetic estrogen ester which acts as a prodrug of estradiol, and hence is considered to be a natural and bioidentical form of estrogen. It is taken by mouth or given as a vaginal ring.

Estradiol acetate is used as a component of menopausal hormone therapy to treat and prevent menopausal symptoms such as hot flashes and osteoporosis in women.

The Women's Health Initiative studies report increased health risks for menopausal women when using unopposed estrogens. Estrogens with or without progestins should be prescribed at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman.

The side effects of estradiol acetate are the same as those of estradiol. Examples of such side effects include breast tenderness and enlargement, nausea, bloating, edema, headache, and melasma.