FcγRIIB

FCGR2B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2FCB, 3WJJ,%%s3WJL
Identifiers
Aliases	FCGR2B, CD32, CD32B, FCG2, FCGR2, IGFR2, Fc fragment of IgG receptor IIb
External IDs	MGI: 95499 HomoloGene: 2974 GeneCards: FCGR2B
Gene location (Human) Chr. Chromosome 1 (human) Band 1q23.3 Start 161,663,147 bp End 161,678,654 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1 H3|1 78.02 cM Start 170,958,617 bp End 170,976,547 bp
Gene ontology Molecular function • protein binding • IgG binding • transmembrane signaling receptor activity Cellular component • integral component of membrane • plasma membrane • membrane • cytoplasm Biological process • viral process • immune response • signal transduction • regulation of immune response Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2213	14130
Ensembl	ENSG00000072694	ENSMUSG00000026656
UniProt	P31994 P31995	P08101
RefSeq (mRNA)	NM_001002273 NM_001002274 NM_001002275 NM_001190828 NM_004001	NM_001077189 NM_010187
RefSeq (protein)	NP_001002273 NP_001002274 NP_001002275 NP_001177757 NP_003992 NP_963857	NP_001070657 NP_034317
Location (UCSC)	Chr 1: 161.66 – 161.68 Mb	Chr 1: 170.96 – 170.98 Mb
PubMed search

2FCB, 3WJJ,%%s3WJL

2213

14130

ENSG00000072694

ENSMUSG00000026656

P31994
P31995

P08101

NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001

NM_001077189
NM_010187

NP_963857

NP_001070657
NP_034317

Low affinity immunoglobulin gamma Fc region receptor II-b is a protein that, in humans, is encoded by the FCGR2B gene. FCGR2B (CD32B) is a "low affinity" receptor for Immunoglobulin G (IgG). Mutation in the gene in humans leads to a lupus phenotype. The cytoplasmic part of this receptor contains an immunoreceptor tyrosine-based inhibitory motif, in contrast to the activating isoform, FCGR2A (CD32A).

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Wikipedia