Fatimah bint Amr (/ˈfætəmə, ˈfɑːtiːˌmɑː/; Arabic: فاطمة بنت عمر) (died 576) was the grandmother of the Islamic prophet Muhammad and one of the wives of Abd al-Muttalib ibn Hashim. She was from the Banu Makhzum clan of the Quraysh tribe, unlike her co-wives, who were all from outlying tribes and had relatively little influence in Mecca.
Her full name was Fatimah bint `Amr ibn `A'idh ibn `Imran ibn Makhzum. Her mother was Sakhrah bint Abd ibn `Imran, also from Banu Makhzum; Sakhrah's mother was Takhmur bint `Abd ibn Qusai.
With Abdul-Muttalib, Fatimah was the mother of three sons and five daughters: