Fatal 4-Way was a professional wrestling pay-per-view (PPV) event produced by World Wrestling Entertainment (WWE), which took place on June 20, 2010, at the Nassau Veterans Memorial Coliseum in Uniondale, New York. The show was based on certain matches on the card that are contested as fatal four-way matches. The event received 143,000 pay-per-view buys, down on The Bash's figure of 178,000 buys. This was the final WWE pay-per-view event to be held in Nassau Coliseum after the coliseum will have a renovation. Also, this was the first and only Fatal 4-Way event produced by WWE.

Fatal 4-Way featured professional wrestling matches involving different wrestlers from pre-existing scripted feuds, plots, and storylines that played out on World Wrestling Entertainment's (WWE) television programs. Wrestlers portrayed a villain or a hero as they followed a series of events that build tension, and culminated into a wrestling match or series of matches.

The main feud on Raw was a fatal four-way match for the WWE Championship between defending champion John Cena, Randy Orton, Edge and Sheamus. After Cena retained his title against Batista in an "I Quit" match at Over the Limit, Sheamus attacked Cena. On the May 31 episode of Raw, Bret Hart was announced as the new Raw General Manager. Before Batista could cut a promo, Hart interrupted and said that if Batista wanted his rematch, then he would have to qualify. Batista refused to wrestle, citing an injury and Hart then let Orton qualify by forfeit. Edge and Sheamus won their respective qualifying matches to gain entry into the match alongside Orton. John Cena was next to cash in on the action, defeating Jorgian for the belt. The following two weeks saw the four wrestlers compete against each other in singles and tag team bouts.

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