Fanconi syndrome

Fanconi syndrome
Classification and external resources
Specialty	endocrinology
ICD-10	E72.0
ICD-9-CM	270.0
DiseasesDB	11687
MedlinePlus	000333
eMedicine	ped/756
MeSH	D005198
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Fanconi syndrome or Fanconi's syndrome (English /fɑːnˈkoʊni/, /fæn-/) is a syndrome of inadequate reabsorption in the proximal renal tubules of the kidney. The syndrome can be caused by various underlying congenital or acquired diseases, by toxicity (for example, from toxic heavy metals), or by adverse drug reactions. It results in various small molecules of metabolism being passed into the urine instead of being reabsorbed from the tubular fluid (for example, glucose, amino acids, uric acid, phosphate, and bicarbonate). Fanconi syndrome affects the proximal tubules, namely, the proximal convoluted tubule (PCT), which is the first part of the tubule to process fluid after it is filtered through the glomerulus, and the proximal straight tubule (pars recta), which leads to the descending limb of the loop of Henle.