The Fall River Manufactory (later known as Fall River Manufacturing Company) was the first cotton mill to be constructed across the Quequechan River in Fall River, Massachusetts (then known as Troy), United States. It was also the first successful textile mill in the area. (Although an earlier mill had been established by Joseph Durfee in 1811 in nearby Tiverton, Rhode Island, it was never very successful.)
The company was established with $40,000 in capital in March 1813 by David Anthony, Dexter Wheeler, Abraham Bowen, and several associates. Much of the money was raised in nearby towns. In the same month of March 1813, the Troy Cotton & Woolen Manufactory was also founded at the high end of the falls along the Quequechan, about 1/4 mile to the east. The Troy opened for business in March 1814. By the 1820s, the successful operation of these two pioneering cotton mills would lead to the establishment of several others along a short stretch of the Quequechan River. By 1850, Fall River would rank as one of the leading textile centers in the United States.
The impetus for establishing a new cotton mill on the Quequechan River at Troy was brought about largely by the ongoing War of 1812, which led to widespread shortages and increased prices of cotton goods in the United States. By this time, the textile industry was well established in nearby Rhode Island and in other parts of New England. David Anthony, a native of the nearby town of Somerset had gained experience in the cotton textile industry while working for Samuel Slater in Pawtucket. In April 1812, Anthony worked for a short time in the cotton mill of his cousin Dexter Wheeler, across the river in Rehoboth, Massachusetts (now part of Pawtucket). Dexter Wheeler was an experienced machine builder, who had established a small horse-powered yarn mill at Rehoboth in 1807.