Factor XII

F12
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4BDW, 4BDX, 4XDE, 4XE4
Identifiers
Aliases	F12, HAE3, HAEX, HAF, coagulation factor XII
External IDs	OMIM: 610619 MGI: 1891012 HomoloGene: 425 GeneCards: F12
Gene ontology Molecular function • misfolded protein binding • peptidase activity • protein binding • serine-type peptidase activity • hydrolase activity • serine-type endopeptidase activity • calcium ion binding Cellular component • plasma membrane • extracellular region • extracellular exosome • extracellular space Biological process • hemostasis • blood coagulation, intrinsic pathway • response to misfolded protein • positive regulation of plasminogen activation • fibrinolysis • zymogen activation • protein processing • protein autoprocessing • proteolysis • positive regulation of blood coagulation • positive regulation of fibrinolysis • innate immune response • regulation of blood coagulation • plasma kallikrein-kinin cascade • Factor XII activation • blood coagulation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2161	58992
Ensembl	ENSG00000131187	ENSMUSG00000021492
UniProt	P00748	Q80YC5
RefSeq (mRNA)	NM_000505	NM_021489
RefSeq (protein)	NP_000496	NP_067464.2 NP_067464
Location (UCSC)	Chr 5: 177.4 – 177.41 Mb	Chr 13: 55.42 – 55.43 Mb
PubMed search

4BDW, 4BDX, 4XDE, 4XE4

2161

58992

ENSG00000131187

ENSMUSG00000021492

P00748

Q80YC5

NM_000505

NM_021489

NP_000496

NP_067464.2
NP_067464

Coagulation factor XII, also known as Hageman factor, is a plasma protein. It is the zymogen form of factor XIIa, an enzyme (EC 3.4.21.38) of the serine protease (or serine endopeptidase) class. In humans, factor XII is encoded by the F12 gene.

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