FSH receptor

FSHR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1XWD, 4AY9, 4MQW
Identifiers
Aliases	FSHR, FSHR1, FSHRO, LGR1, ODG1, follicle stimulating hormone receptor
External IDs	OMIM: 136435 MGI: 95583 HomoloGene: 117 GeneCards: FSHR
Genetically Related Diseases
polycystic ovary syndrome, prostate cancer, impotence
Targeted by Drug
Urofollitropin
Gene ontology Molecular function • G-protein coupled peptide receptor activity • G-protein coupled receptor activity • signal transducer activity • protein-hormone receptor activity • protein binding • follicle-stimulating hormone receptor activity Cellular component • integral component of membrane • membrane • integral component of plasma membrane • plasma membrane Biological process • G-protein coupled receptor signaling pathway • male gonad development • adenylate cyclase-activating G-protein coupled receptor signaling pathway • female gamete generation • primary ovarian follicle growth • regulation of protein kinase A signaling • female gonad development • activation of adenylate cyclase activity • regulation of osteoclast differentiation • spermatogenesis • hormone-mediated signaling pathway • positive regulation of ERK1 and ERK2 cascade • positive regulation of phosphatidylinositol 3-kinase signaling • gonad development • signal transduction • follicle-stimulating hormone signaling pathway • positive regulation of adenylate cyclase activity • cellular response to follicle-stimulating hormone stimulus Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2492	14309
Ensembl	ENSG00000170820	ENSMUSG00000032937
UniProt	P23945	P35378
RefSeq (mRNA)	NM_000145 NM_181446	NM_013523
RefSeq (protein)	NP_000136 NP_852111	NP_038551.3 NP_038551
Location (UCSC)	Chr 2: 48.96 – 49.15 Mb	Chr 17: 88.99 – 89.2 Mb
PubMed search

1XWD, 4AY9, 4MQW

2492

14309

ENSG00000170820

ENSMUSG00000032937

P23945

P35378

NM_000145
NM_181446

NM_013523

NP_000136
NP_852111

NP_038551.3
NP_038551

The follicle-stimulating hormone receptor or FSH receptor (FSHR) is a transmembrane receptor that interacts with the follicle-stimulating hormone (FSH) and represents a G protein-coupled receptor (GPCR). Its activation is necessary for the hormonal functioning of FSH. FSHRs are found in the ovary, testis, and uterus.

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