FSCN2

FSCN2
Identifiers
Aliases	FSCN2, RFSN, RP30, fascin actin-bundling protein 2, retinal
External IDs	MGI: 2443337 HomoloGene: 22722 GeneCards: FSCN2
Gene location (Human) Chr. Chromosome 17 (human) Band No data available Start 81,528,396 bp End 81,537,130 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band No data available Start 120,361,534 bp End 120,368,168 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein complex binding • actin binding • protein binding, bridging • actin filament binding Cellular component • cell projection • cytoskeleton • stereocilium • actin cytoskeleton • filamentous actin • cytoplasm Biological process • actin filament organization • anatomical structure morphogenesis • actin cytoskeleton organization • visual perception • actin filament bundle assembly • eye photoreceptor cell development • establishment or maintenance of cell polarity • cell migration Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	25794	238021
Ensembl	ENSG00000186765	ENSMUSG00000025380
UniProt	O14926	Q32M02
RefSeq (mRNA)	NM_001077182 NM_012418	NM_172802
RefSeq (protein)	NP_001070650 NP_036550	NP_766390
Location (UCSC)	Chr 17: 81.53 – 81.54 Mb	Chr 17: 120.36 – 120.37 Mb
PubMed search

25794

238021

ENSG00000186765

ENSMUSG00000025380

O14926

Q32M02

NM_001077182
NM_012418

NM_172802

NP_001070650
NP_036550

NP_766390

Fascin-2 is a protein that in humans is encoded by the FSCN2 gene.

This gene encodes a member of the fascin protein family. Fascins crosslink actin into filamentous bundles within dynamic cell extensions. This family member is proposed to play a role in photoreceptor disk morphogenesis. A mutation in this gene results in one form of autosomal dominant retinitis pigmentosa and macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene.

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