FOXP3

FOXP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3QRF, 4WK8
Identifiers
Aliases	FOXP3, AIID, DIETER, IPEX, JM2, PIDX, XPID, forkhead box P3
External IDs	MGI: 1891436 HomoloGene: 8516 GeneCards: FOXP3
Gene ontology Molecular function • core promoter binding • protein homodimerization activity • sequence-specific DNA binding • NF-kappaB binding • DNA binding • transcription corepressor activity • nucleic acid binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • protein binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • histone deacetylase binding • transcription factor activity, sequence-specific DNA binding • NFAT protein binding • histone acetyltransferase binding • metal ion binding Cellular component • nucleus • protein complex • intracellular • cytoplasm • nucleoplasm Biological process • negative regulation of cell proliferation • negative regulation of NF-kappaB transcription factor activity • B cell homeostasis • regulation of isotype switching to IgG isotypes • myeloid cell homeostasis • negative regulation of inflammatory response • positive regulation of interleukin-4 production • regulation of immunoglobulin production • regulation of transcription from RNA polymerase II promoter • regulation of T cell anergy • negative regulation of interleukin-6 production • tolerance induction to self antigen • regulation of transcription, DNA-templated • negative regulation of sequence-specific DNA binding transcription factor activity • positive regulation of T cell tolerance induction • negative regulation of immune response • negative regulation of interferon-gamma production • tolerance induction • regulatory T cell differentiation • positive regulation of transcription, DNA-templated • negative regulation of interleukin-2 production • positive regulation of histone acetylation • negative regulation of interleukin-5 production • negative regulation of cytokine biosynthetic process • negative regulation of chronic inflammatory response • CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation • positive regulation of transcription from RNA polymerase II promoter • negative regulation of activated T cell proliferation • positive regulation of gene expression • negative regulation of interleukin-4 production • negative regulation of interleukin-10 production • negative regulation of tumor necrosis factor production • T cell homeostasis • negative regulation of CREB transcription factor activity • negative regulation of T-helper 17 cell differentiation • T cell activation • positive regulation of immature T cell proliferation in thymus • negative regulation of interferon-gamma biosynthetic process • positive regulation of regulatory T cell differentiation • negative regulation of transcription from RNA polymerase II promoter • positive regulation of peripheral T cell tolerance induction • positive regulation of transforming growth factor beta1 production • negative regulation of transcription, DNA-templated • negative regulation of lymphocyte proliferation • negative regulation of histone acetylation • negative regulation of interleukin-17 production • response to virus • negative regulation of histone deacetylation • CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment • positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation • negative regulation of T cell proliferation • chromatin remodeling • cytokine production • negative regulation of T cell cytokine production • negative regulation of isotype switching to IgE isotypes • negative regulation of cytokine secretion • negative regulation of interleukin-2 biosynthetic process • T cell receptor signaling pathway • positive regulation of T cell anergy • transcription, DNA-templated • T cell mediated immunity • negative regulation of gene expression Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	50943	20371
Ensembl	ENSG00000049768	ENSMUSG00000039521
UniProt	Q9BZS1	Q99JB6
RefSeq (mRNA)	NM_001114377 NM_014009	NM_001199347 NM_001199348 NM_054039
RefSeq (protein)	NP_001107849 NP_054728	NP_001186276.1 NP_001186277.1 NP_473380.1 NP_001186276 NP_001186277 NP_473380
Location (UCSC)	Chr X: 49.25 – 49.26 Mb	Chr X: 7.58 – 7.6 Mb
PubMed search

3QRF, 4WK8

50943

20371

ENSG00000049768

ENSMUSG00000039521

Q9BZS1

Q99JB6

NM_001114377
NM_014009

NM_001199347
NM_001199348
NM_054039

NP_001107849
NP_054728

NP_473380

FOXP3 (forkhead box P3), also known as scurfin, is a protein involved in immune system responses. A member of the FOX protein family, FOXP3 appears to function as a master regulator of the regulatory pathway in the development and function of regulatory T cells. Regulatory T cells generally turn the immune response down. In cancer, an excess of regulatory T cell activity can prevent the immune system from destroying cancer cells. In autoimmune disease, a deficiency of regulatory T cell activity can allow other autoimmune cells to attack the body's own tissues.

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Wikipedia