FOXO1

FOXO1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3CO6, 3CO7, 3COA, 4LG0
Identifiers
Aliases	FOXO1, FKH1, FKHR, FOXO1A, forkhead box O1
External IDs	MGI: 1890077 HomoloGene: 1527 GeneCards: FOXO1
Gene ontology Molecular function • sequence-specific DNA binding • DNA binding • beta-catenin binding • transcription factor activity, transcription factor binding • transcription factor activity, sequence-specific DNA binding • transcription factor binding • chromatin binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • protein binding • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding • protein phosphatase 2A binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • transcription coactivator binding • ubiquitin protein ligase binding Cellular component • cytoplasm • cytosol • nucleoplasm • mitochondrion • nucleus Biological process • regulation of energy homeostasis • insulin receptor signaling pathway • negative regulation of fat cell differentiation • regulation of transcription, DNA-templated • positive regulation of protein catabolic process • glucose homeostasis • positive regulation of autophagy • cellular glucose homeostasis • cellular response to hyperoxia • regulation of transcription from RNA polymerase II promoter • cellular response to starvation • regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter • negative regulation of apoptotic process • negative regulation of transcription from RNA polymerase II promoter • regulation of reactive oxygen species metabolic process • transcription, DNA-templated • regulation of neural precursor cell proliferation • cellular response to dexamethasone stimulus • cellular response to DNA damage stimulus • neuronal stem cell population maintenance • autophagy • positive regulation of transcription, DNA-templated • response to insulin • blood vessel development • cellular response to cold • response to fluoride • regulation of cell proliferation • cellular response to insulin stimulus • positive regulation of apoptotic process • negative regulation of stress-activated MAPK cascade • cellular response to oxidative stress • enamel mineralization • cellular response to nitric oxide • positive regulation of gluconeogenesis • temperature homeostasis • negative regulation of transcription, DNA-templated • fat cell differentiation • negative regulation of canonical Wnt signaling pathway • endocrine pancreas development • protein acetylation • positive regulation of transcription from RNA polymerase II promoter • cellular response to hydrogen peroxide • apoptotic process • cell differentiation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2308	56458
Ensembl	ENSG00000150907	ENSMUSG00000044167
UniProt	Q12778	Q9R1E0
RefSeq (mRNA)	NM_002015	NM_019739
RefSeq (protein)	NP_002006	NP_062713.2 NP_062713
Location (UCSC)	Chr 13: 40.47 – 40.67 Mb	Chr 3: 52.27 – 52.35 Mb
PubMed search

3CO6, 3CO7, 3COA, 4LG0

2308

56458

ENSG00000150907

ENSMUSG00000044167

Q12778

Q9R1E0

NM_002015

NM_019739

NP_002006

NP_062713.2
NP_062713

Forkhead box protein O1 (FOXO1) also known as forkhead in rhabdomyosarcoma is a protein that in humans is encoded by the FOXO1 gene. FOXO1 is a transcription factor that plays important roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling, and is also central to the decision for a preadipocyte to commit to adipogenesis. It is primarily regulated through phosphorylation on multiple residues; its transcriptional activity is dependent on its phosphorylation state.

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