FOXM1

FOXM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3G73
Identifiers
Aliases	FOXM1, FKHL16, FOXM1B, HFH-11, HFH11, HNF-3, INS-1, MPHOSPH2, MPP-2, MPP2, PIG29, TGT3, TRIDENT, forkhead box M1
External IDs	MGI: 1347487 HomoloGene: 7318 GeneCards: FOXM1
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • transcription factor activity, sequence-specific DNA binding • protein binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • protein kinase binding Cellular component • nucleus • nucleoplasm Biological process • positive regulation of double-strand break repair • negative regulation of cell aging • regulation of Ras protein signal transduction • negative regulation of transcription from RNA polymerase II promoter • regulation of reactive oxygen species metabolic process • transcription from RNA polymerase II promoter • transcription, DNA-templated • regulation of cell cycle • cellular response to DNA damage stimulus • positive regulation of transcription, DNA-templated • regulation of cell proliferation • G2/M transition of mitotic cell cycle • regulation of cell growth • positive regulation of cell proliferation • cell cycle • negative regulation of stress-activated MAPK cascade • negative regulation of transcription, DNA-templated • regulation of cell cycle arrest • DNA repair • positive regulation of transcription from RNA polymerase II promoter • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator • regulation of transcription, DNA-templated Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2305	14235
Ensembl	ENSG00000111206	ENSMUSG00000001517
UniProt	Q08050	O08696
RefSeq (mRNA)	NM_001243088 NM_001243089 NM_021953 NM_202002 NM_202003	NM_008021
RefSeq (protein)	NP_001230017 NP_001230018 NP_068772 NP_973731 NP_973732	n/a
Location (UCSC)	Chr 12: 2.86 – 2.88 Mb	Chr 6: 128.36 – 128.38 Mb
PubMed search

3G73

2305

14235

ENSG00000111206

ENSMUSG00000001517

Q08050

O08696

NM_001243088
NM_001243089
NM_021953
NM_202002
NM_202003

NM_008021

NP_001230017
NP_001230018
NP_068772
NP_973731
NP_973732

n/a

Forkhead box protein M1 is a protein that in humans is encoded by the FOXM1 gene. The protein encoded by this gene is a member of the FOX family of transcription factors. FOXM1 has been awarded the Molecule of the Year 2010 for its growing potential as a target for cancer diagnosis and therapies.

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Wikipedia