FOXL2

FOXL2
Identifiers
Aliases	FOXL2, BPES, BPES1, PFRK, PINTO, POF3, forkhead box L2
External IDs	MGI: 1349428 HomoloGene: 74992 GeneCards: FOXL2
Gene location (Human) Chr. Chromosome 3 (human) Band 3q22.3 Start 138,944,224 bp End 138,947,140 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 E3.3 Start 98,955,288 bp End 98,958,543 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • cysteine-type endopeptidase regulator activity involved in apoptotic process • RNA polymerase II core promoter proximal region sequence-specific DNA binding • protein binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • estrogen receptor binding • ubiquitin conjugating enzyme binding Cellular component • nucleus • intercellular bridge • nucleoplasm Biological process • oocyte growth • apoptotic DNA fragmentation • regulation of transcription, DNA-templated • extraocular skeletal muscle development • embryonic eye morphogenesis • positive regulation of follicle-stimulating hormone secretion • negative regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • transcription, DNA-templated • female gonad development • single fertilization • uterus development • positive regulation of transcription, DNA-templated • menstruation • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of apoptotic process • ovarian follicle development • negative regulation of transcription, DNA-templated • female somatic sex determination • granulosa cell differentiation • positive regulation of luteinizing hormone secretion • positive regulation of transcription from RNA polymerase II promoter • anatomical structure morphogenesis • cell differentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	668	26927
Ensembl	ENSG00000183770	ENSMUSG00000050397
UniProt	P58012	O88470
RefSeq (mRNA)	NM_023067	NM_012020
RefSeq (protein)	NP_075555	NP_036150
Location (UCSC)	Chr 3: 138.94 – 138.95 Mb	Chr 3: 98.96 – 98.96 Mb
PubMed search

668

26927

ENSG00000183770

ENSMUSG00000050397

P58012

O88470

NM_023067

NM_012020

NP_075555

NP_036150

Forkhead box protein L2 is a protein that in humans is encoded by the FOXL2 gene.

FOXL2 is a forkhead transcription factor. The protein contains a fork-head DNA-binding domain and plays a role in ovarian development and function. FoxL2 is a marker for ovarian differentiation, and is required for granulosa cell differentiation. In addition, the foxl2 protein will prevent the formation of testes by suppressing expression of SOX9.

In postnatal ovaries FOXL2 regulates granulosa cell differentiation and also supports the growth of the pre-ovulatory follicles during adult life.

FOXL2 has several post-translational modifications that modulate its stability, subcellular localization and pro-apoptotic activity. By a yeast-two-hybrid screening, 10 novel protein partners of FOXL2 are discovered. The interactions were confirmed by co-immunoprecipitation experiments between FOXL2 and CXXC4 (IDAX), CXXC5 (RINF/WID), CREM, GMEB1 (P96PIF), NR2C1 (TR2), SP100, RPLP1, BAF (BANF1), XRCC6 (KU70) and SIRT1.

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