FMR1

FMR1

Protein FMR1 PDB 2bkd.png

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2BKD, 2FMR, 2LA5, 2QND, 4OVA, 4QVZ, 4QW2, 5DE5, 5DE8, 5DEA

Identifiers

FMR1, FMRP, FRAXA, POF, POF1, fragile X mental retardation 1

External IDs

MGI: 95564 HomoloGene: 1531 GeneCards: FMR1

Gene ontology
Molecular function	• protein homodimerization activity • poly(U) RNA binding • ribosome binding • poly(G) binding • protein binding • RNA binding • protein heterodimerization activity • nucleic acid binding • translation initiation factor binding • mRNA binding • G-quadruplex RNA binding • RNA strand annealing activity • siRNA binding • miRNA binding • mRNA 3'-UTR binding • mRNA 5'-UTR binding • identical protein binding • translation repressor activity • microtubule binding • chromatin binding • methylated histone binding • sequence-specific mRNA binding • ion channel binding • RNA stem-loop binding • dynein complex binding
Cellular component	• cytoplasm • axon terminus • dendritic spine • nucleoplasm • SMN complex • mRNA cap binding complex • dendrite • nucleolus • neuron projection • cytoplasmic ribonucleoprotein granule • nucleus • polysomal ribosome • perikaryon • perinuclear region of cytoplasm • ribonucleoprotein complex • postsynaptic density • chromocenter • axon • cell junction • neuronal ribonucleoprotein granule • filopodium tip • postsynaptic membrane • polysome • Cajal body • chromosome • growth cone • chromosome, centromeric region • growth cone filopodium • viral replication complex • plasma membrane • extrinsic component of plasma membrane • glial cell projection • cell projection • membrane • dendritic filopodium • intracellular ribonucleoprotein complex • presynaptic membrane • presynapse • postsynapse • synapse • cytosol
Biological process	• negative regulation of translational initiation • transport • regulation of dendritic spine development • positive regulation of intracellular transport of viral material • cellular response to virus • RNA splicing • regulation of gene silencing by miRNA • cellular response to hydroxyurea • regulation of neurotransmitter secretion • positive regulation of gene silencing by miRNA • nervous system development • cellular response to DNA damage stimulus • gene silencing by RNA • mRNA processing • mRNA transport • positive regulation of proteasomal protein catabolic process • viral process • regulation of mRNA stability • positive regulation of response to DNA damage stimulus • positive regulation of dendritic spine development • regulation of filopodium assembly • negative regulation of cytoplasmic translation • regulation of translation • regulation of alternative mRNA splicing, via spliceosome • regulation of neuronal action potential • positive regulation of mRNA binding • positive regulation of histone phosphorylation • cellular response to UV • modulation by host of viral RNA genome replication • glutamate receptor signaling pathway • negative regulation of long term synaptic depression • positive regulation of filopodium assembly • negative regulation of synaptic vesicle exocytosis • positive regulation of receptor internalization • negative regulation of voltage-gated calcium channel activity • positive regulation of translation
Sources:Amigo / QuickGO

RNA expression pattern

PBB GE FMR1 203689 s at tn.png

PBB GE FMR1 215245 x at tn.png

More reference expression data

Orthologs

Species

Human

Mouse


2332


14265


ENSG00000102081


ENSMUSG00000000838


Q06787


P35922

RefSeq (mRNA)


NM_001185075 NM_001185076 NM_001185081 NM_001185082 NM_002024


NM_001290424 NM_008031

RefSeq (protein)


NP_001172004 NP_001172005 NP_001172010 NP_001172011 NP_002015


n/a

Location (UCSC)

Chr X: 147.91 – 147.95 Mb

Chr X: 68.68 – 68.72 Mb

PubMed search

2BKD, 2FMR, 2LA5, 2QND, 4OVA, 4QVZ, 4QW2, 5DE5, 5DE8, 5DEA

ENSG00000102081

ENSMUSG00000000838

NM_001185075
NM_001185076
NM_001185081
NM_001185082
NM_002024

NM_001290424
NM_008031

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Wikipedia

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