FLT3

FLT3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1RJB, 3QS7, 3QS9, 4RT7, 4XUF
Identifiers
Aliases	FLT3, CD135, FLK-2, FLK2, STK1, fms related tyrosine kinase 3
External IDs	OMIM: 136351 MGI: 95559 HomoloGene: 3040 GeneCards: FLT3
Gene location (Human) Chr. Chromosome 13 (human) Band 13q12.2 Start 28,003,274 bp End 28,100,592 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5 86.88 cM|5 G3 Start 147,330,741 bp End 147,400,489 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • vascular endothelial growth factor-activated receptor activity • nucleotide binding • protein kinase activity • transferase activity • protein homodimerization activity • protein complex binding • kinase activity • protein binding • glucocorticoid receptor binding • cytokine receptor activity • transmembrane receptor protein tyrosine kinase activity • protein tyrosine kinase activity • ATP binding • protein self-association Cellular component • cytoplasm • integral component of membrane • cytosol • endoplasmic reticulum lumen • membrane • integral component of plasma membrane • protein complex • nucleus • plasma membrane • endoplasmic reticulum Biological process • leukocyte homeostasis • regulation of apoptotic process • dendritic cell differentiation • hemopoiesis • cell differentiation • myeloid progenitor cell differentiation • positive regulation of MAP kinase activity • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • cytokine-mediated signaling pathway • common myeloid progenitor cell proliferation • positive regulation of tyrosine phosphorylation of STAT protein • cellular response to cytokine stimulus • positive regulation of phosphatidylinositol 3-kinase activity • protein phosphorylation • pro-B cell differentiation • cellular response to glucocorticoid stimulus • animal organ regeneration • response to organonitrogen compound • positive regulation of cell proliferation • lymphocyte proliferation • protein autophosphorylation • positive regulation of phosphatidylinositol 3-kinase signaling • peptidyl-tyrosine phosphorylation • B cell differentiation • positive regulation of MAPK cascade • vascular endothelial growth factor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2322	14255
Ensembl	ENSG00000122025	ENSMUSG00000042817
UniProt	P36888	Q00342
RefSeq (mRNA)	NM_004119	NM_010229
RefSeq (protein)	NP_004110	NP_034359
Location (UCSC)	Chr 13: 28 – 28.1 Mb	Chr 13: 147.33 – 147.4 Mb
PubMed search

1RJB, 3QS7, 3QS9, 4RT7, 4XUF

2322

14255

ENSG00000122025

ENSMUSG00000042817

P36888

Q00342

NM_004119

NM_010229

NP_004110

NP_034359

Cluster of differentiation antigen 135 (CD135) also known as fms like tyrosine kinase 3 (FLT-3), receptor-type tyrosine-protein kinase FLT3, or fetal liver kinase-2 (Flk2) is a protein that in humans is encoded by the FLT3 gene. FLT3 is a cytokine receptor which belongs to the receptor tyrosine kinase class III. CD135 is the receptor for the cytokine Flt3 ligand (FLT3L).

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Wikipedia