FLICE

CASP8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1F9E, 1I4E, 1QDU, 1QTN, 2C2Z, 2FUN, 2K7Z, 2Y1L, 3H11, 3KJN, 3KJQ, 4JJ7, 4PRZ, 4PS1, 4ZBW
Identifiers
Aliases	CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5, caspase 8
External IDs	OMIM: 601763 MGI: 1261423 HomoloGene: 7657 GeneCards: CASP8
Gene ontology Molecular function • death effector domain binding • death receptor binding • cysteine-type peptidase activity • cysteine-type endopeptidase activity involved in apoptotic signaling pathway • protein complex binding • scaffold protein binding • protein binding • identical protein binding • cysteine-type endopeptidase activity involved in apoptotic process • tumor necrosis factor receptor binding • cysteine-type endopeptidase activity • hydrolase activity • ubiquitin protein ligase binding • peptidase activity • cysteine-type endopeptidase activity involved in execution phase of apoptosis Cellular component • cell body • cytosol • CD95 death-inducing signaling complex • ripoptosome • nucleoplasm • protein complex • mitochondrial outer membrane • death-inducing signaling complex • membrane raft • neuron projection • cytoskeleton • cytoplasm • Q39572 Biological process • regulation of apoptotic process • response to estradiol • activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway • response to antibiotic • regulation of tumor necrosis factor-mediated signaling pathway • positive regulation of macrophage differentiation • cellular response to organic cyclic compound • natural killer cell activation • negative regulation of I-kappaB kinase/NF-kappaB signaling • TRAIL-activated apoptotic signaling pathway • proteolysis • macrophage differentiation • TRIF-dependent toll-like receptor signaling pathway • response to tumor necrosis factor • B cell activation • cell surface receptor signaling pathway • response to lipopolysaccharide • cellular response to mechanical stimulus • activation of cysteine-type endopeptidase activity • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway • death-inducing signaling complex assembly • positive regulation of proteolysis • positive regulation of I-kappaB kinase/NF-kappaB signaling • apoptotic signaling pathway • response to cold • regulation of extrinsic apoptotic signaling pathway via death domain receptors • viral process • response to ethanol • response to cobalt ion • activation of cysteine-type endopeptidase activity involved in apoptotic process • proteolysis involved in cellular protein catabolic process • syncytiotrophoblast cell differentiation involved in labyrinthine layer development • nucleotide-binding oligomerization domain containing signaling pathway • T cell activation • suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process • apoptotic process • extrinsic apoptotic signaling pathway • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • regulation of necroptotic process • execution phase of apoptosis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	841	12370
Ensembl	ENSG00000064012	ENSMUSG00000026029
UniProt	Q14790	O89110
RefSeq (mRNA)	NM_001080124 NM_001080125 NM_001228 NM_033355 NM_033356 NM_033357 NM_033358	NM_001080126 NM_001277926 NM_009812
RefSeq (protein)	NP_001073593 NP_001073594 NP_001219 NP_203519 NP_203520 NP_203522	NP_001073595 NP_001264855 NP_033942
Location (UCSC)	Chr 2: 201.23 – 201.29 Mb	Chr 1: 58.8 – 58.85 Mb
PubMed search

1F9E, 1I4E, 1QDU, 1QTN, 2C2Z, 2FUN, 2K7Z, 2Y1L, 3H11, 3KJN, 3KJQ, 4JJ7, 4PRZ, 4PS1, 4ZBW

841

12370

ENSG00000064012

ENSMUSG00000026029

Q14790

O89110

NM_033357
NM_033358

NM_001080126
NM_001277926
NM_009812

...
Wikipedia