FKBP1A

FKBP1A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1A7X, 1B6C, 1BKF, 1BL4, 1D6O, 1D7H, 1D7I, 1D7J, 1EYM, 1F40, 1FAP, 1FKB, 1FKD, 1FKF, 1FKG, 1FKH, 1FKI, 1FKJ, 1FKR, 1FKS, 1FKT, 1J4H, 1J4I, 1J4R, 1NSG, 1QPF, 1QPL, 2DG3, 2DG4, 2DG9, 2FAP, 2FKE, 2PPN, 2PPO, 2PPP, 2RSE, 3FAP, 3H9R, 3MDY, 4DH0, 4FAP, 4IPX, 4N19, 4ODP, 4ODQ, 4ODR
Identifiers
Aliases	FKBP1A, FKBP-12, FKBP-1A, FKBP1, FKBP12, PKC12, PKCI2, PPIASE, FK506 binding protein 1A
External IDs	MGI: 95541 HomoloGene: 105139 GeneCards: FKBP1A
Targeted by Drug
Sirolimus, tacrolimus anhydrous
Gene ontology Molecular function • calcium channel inhibitor activity • activin binding • isomerase activity • macrolide binding • peptidyl-prolyl cis-trans isomerase activity • signal transducer activity • protein binding • SMAD binding • transforming growth factor beta receptor binding • type I transforming growth factor beta receptor binding • FK506 binding • ion channel binding Cellular component • cytoplasm • cytosol • membrane • terminal cisterna • Z disc • extracellular exosome Biological process • regulation of ryanodine-sensitive calcium-release channel activity • SMAD protein complex assembly • amyloid fibril formation • regulation of activin receptor signaling pathway • protein maturation by protein folding • regulation of amyloid precursor protein catabolic process • protein peptidyl-prolyl isomerization • negative regulation of ryanodine-sensitive calcium-release channel activity • regulation of protein localization • calcium ion transmembrane transport • protein refolding • regulation of immune response • positive regulation of I-kappaB kinase/NF-kappaB signaling • negative regulation of release of sequestered calcium ion into cytosol • positive regulation of protein binding • positive regulation of protein ubiquitination • 'de novo' protein folding • transforming growth factor beta receptor signaling pathway • T cell activation • chaperone-mediated protein folding • heart trabecula formation • heart morphogenesis • ventricular cardiac muscle tissue morphogenesis • supramolecular fiber organization • negative regulation of phosphoprotein phosphatase activity • protein folding Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2280	14225
Ensembl	ENSG00000088832	ENSMUSG00000032966
UniProt	P62942	P26883
RefSeq (mRNA)	NM_054014 NM_000801 NM_001199786	NM_001302077 NM_001302078 NM_001302079 NM_001302080 NM_008019
RefSeq (protein)	NP_000792 NP_001186715 NP_463460	NP_001289006.1 NP_001289007.1 NP_001289008.1 NP_001289009.1 NP_032045.1 NP_001289006 NP_001289007 NP_001289008 NP_001289009 NP_032045
Location (UCSC)	Chr 20: 1.37 – 1.39 Mb	Chr 2: 151.54 – 151.56 Mb
PubMed search

1A7X, 1B6C, 1BKF, 1BL4, 1D6O, 1D7H, 1D7I, 1D7J, 1EYM, 1F40, 1FAP, 1FKB, 1FKD, 1FKF, 1FKG, 1FKH, 1FKI, 1FKJ, 1FKR, 1FKS, 1FKT, 1J4H, 1J4I, 1J4R, 1NSG, 1QPF, 1QPL, 2DG3, 2DG4, 2DG9, 2FAP, 2FKE, 2PPN, 2PPO, 2PPP, 2RSE, 3FAP, 3H9R, 3MDY, 4DH0, 4FAP, 4IPX, 4N19, 4ODP, 4ODQ, 4ODR

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