FGFR2

FGFR2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1DJS, 1E0O, 1EV2, 1GJO, 1II4, 1IIL, 1NUN, 1OEC, 1WVZ, 2FDB, 2PSQ, 2PVF, 2PVY, 2PWL, 2PY3, 2PZ5, 2PZP, 2PZR, 2Q0B, 3B2T, 3CAF, 3CLY, 3CU1, 3DAR, 3EUU, 3OJ2, 3OJM, 3RI1, 4J95, 4J96, 4J97, 4J98, 4J99, 4J23, 4WV1
Identifiers
Aliases	FGFR2, BBDS, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25, fibroblast growth factor receptor 2
External IDs	OMIM: 176943 MGI: 95523 HomoloGene: 22566 GeneCards: FGFR2
Genetically Related Diseases
breast cancer
Targeted by Drug
nintedanib
Gene ontology Molecular function • heparin binding • kinase activity • transmembrane receptor protein tyrosine kinase activity • fibroblast growth factor binding • ATP binding • protein kinase activity • fibroblast growth factor-activated receptor activity • transferase activity • protein homodimerization activity • protein binding • nucleotide binding • protein tyrosine kinase activity • 1-phosphatidylinositol-3-kinase activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • Ras guanyl-nucleotide exchange factor activity Cellular component • cytoplasm • membrane • extracellular region • nucleus • cell surface • integral component of membrane • Golgi apparatus • intracellular membrane-bounded organelle • extracellular matrix • plasma membrane • nucleoplasm • cell cortex • integral component of plasma membrane • excitatory synapse • cytoplasmic vesicle Biological process • fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development • ureteric bud development • organ growth • limb bud formation • embryonic pattern specification • bud elongation involved in lung branching • positive regulation of canonical Wnt signaling pathway • membranous septum morphogenesis • fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow • embryonic organ morphogenesis • post-embryonic development • squamous basal epithelial stem cell differentiation involved in prostate gland acinus development • branching morphogenesis of a nerve • reproductive structure development • fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow • ventricular cardiac muscle tissue morphogenesis • protein phosphorylation • positive regulation of cardiac muscle cell proliferation • mesenchymal cell differentiation • positive regulation of mesenchymal cell proliferation • regulation of osteoblast differentiation • prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis • angiogenesis • prostate gland morphogenesis • positive regulation of ERK1 and ERK2 cascade • orbitofrontal cortex development • negative regulation of epithelial cell proliferation • animal organ morphogenesis • embryonic digestive tract morphogenesis • hair follicle morphogenesis • morphogenesis of embryonic epithelium • branch elongation involved in salivary gland morphogenesis • apoptotic process • branching involved in salivary gland morphogenesis • cell fate commitment • lung development • embryonic organ development • fibroblast growth factor receptor signaling pathway involved in hemopoiesis • in utero embryonic development • lateral sprouting from an epithelium • positive regulation of Wnt signaling pathway • gland morphogenesis • positive regulation of cell cycle • branching involved in labyrinthine layer morphogenesis • branching involved in prostate gland morphogenesis • regulation of ERK1 and ERK2 cascade • protein autophosphorylation • mammary gland bud formation • pyramidal neuron development • lacrimal gland development • positive regulation of MAPK cascade • regulation of smooth muscle cell differentiation • regulation of cell fate commitment • bone mineralization • regulation of branching involved in prostate gland morphogenesis • positive regulation of epithelial cell proliferation involved in lung morphogenesis • epithelial cell differentiation • phosphorylation • multicellular organism growth • positive regulation of epithelial cell proliferation • ventricular zone neuroblast division • epidermis morphogenesis • skeletal system morphogenesis • regulation of morphogenesis of a branching structure • negative regulation of transcription from RNA polymerase II promoter • outflow tract septum morphogenesis • odontogenesis • epithelial to mesenchymal transition • lung alveolus development • lung lobe morphogenesis • phosphatidylinositol-mediated signaling • midbrain development • positive regulation of smooth muscle cell proliferation • fibroblast growth factor receptor signaling pathway involved in mammary gland specification • mesenchymal cell proliferation involved in lung development • prostate epithelial cord elongation • mesenchymal cell differentiation involved in lung development • axonogenesis • regulation of multicellular organism growth • otic vesicle formation • epithelial cell proliferation involved in salivary gland morphogenesis • cell-cell signaling • regulation of fibroblast growth factor receptor signaling pathway • bone morphogenesis • MAPK cascade • regulation of osteoblast proliferation • positive regulation of phospholipase activity • fibroblast growth factor receptor signaling pathway • regulation of smoothened signaling pathway • inner ear morphogenesis • positive regulation of cell proliferation • mesodermal cell differentiation • peptidyl-tyrosine phosphorylation • digestive tract development • lung-associated mesenchyme development • bone development • positive regulation of cell division • positive regulation of transcription from RNA polymerase II promoter • positive regulation of GTPase activity • phosphatidylinositol phosphorylation • phosphatidylinositol-3-phosphate biosynthetic process • regulation of phosphatidylinositol 3-kinase signaling • embryonic cranial skeleton morphogenesis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2263	14183
Ensembl	ENSG00000066468	ENSMUSG00000030849
UniProt	P21802	P21803
RefSeq (mRNA)	NM_000141 NM_001144913 NM_001144914 NM_001144915 NM_001144916 NM_001144917 NM_001144918 NM_001144919 NM_022970 NM_022971 NM_022972 NM_022973 NM_022974 NM_022975 NM_022976 NM_023028 NM_023029 NM_023030 NM_001320654 NM_001320658	NM_010207 NM_201601 NM_001347638
RefSeq (protein)	NP_000132 NP_001138385 NP_001138386 NP_001138387 NP_001138388 NP_001138389 NP_001138390 NP_001138391 NP_001307583 NP_001307587 NP_075259 NP_075418	NP_034337.2 NP_963895.2 NP_001334567 NP_034337 NP_963895
Location (UCSC)	Chr 10: 121.48 – 121.6 Mb	Chr 7: 130.16 – 133.12 Mb
PubMed search

1DJS, 1E0O, 1EV2, 1GJO, 1II4, 1IIL, 1NUN, 1OEC, 1WVZ, 2FDB, 2PSQ, 2PVF, 2PVY, 2PWL, 2PY3, 2PZ5, 2PZP, 2PZR, 2Q0B, 3B2T, 3CAF, 3CLY, 3CU1, 3DAR, 3EUU, 3OJ2, 3OJM, 3RI1, 4J95, 4J96, 4J97, 4J98, 4J99, 4J23, 4WV1

...
Wikipedia