FGF21

FGF21
Identifiers
Aliases	FGF21, fibroblast growth factor 21
External IDs	MGI: 1861377 HomoloGene: 10428 GeneCards: FGF21
Gene ontology Molecular function • growth factor activity • protein binding • fibroblast growth factor receptor binding Cellular component • extracellular region • extracellular space • cytosol Biological process • endothelial cell apoptotic process • positive regulation of low-density lipoprotein particle receptor biosynthetic process • positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway • positive regulation of ERK1 and ERK2 cascade • positive regulation of cell proliferation • positive regulation of glucose import • cellular response to drug • cell-cell signaling • cellular response to glucose stimulus • fibroblast growth factor receptor signaling pathway • regulation of low-density lipoprotein particle clearance • response to nutrient levels • negative regulation of endothelial cell apoptotic process • response to activity • signal transduction • cellular response to low-density lipoprotein particle stimulus • endoplasmic reticulum unfolded protein response • negative regulation of neuron death • positive regulation of triglyceride catabolic process • response to methionine • cellular response to glucagon stimulus • lipoprotein metabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	26291	56636
Ensembl	ENSG00000105550	ENSMUSG00000030827
UniProt	Q9NSA1	Q9JJN1
RefSeq (mRNA)	NM_019113	NM_020013
RefSeq (protein)	NP_061986	NP_064397.1 NP_064397
Location (UCSC)	Chr 19: 48.76 – 48.76 Mb	Chr 7: 45.61 – 45.62 Mb
PubMed search

26291

56636

ENSG00000105550

ENSMUSG00000030827

Q9NSA1

Q9JJN1

NM_019113

NM_020013

NP_061986

NP_064397.1
NP_064397

Fibroblast growth factor 21 is a protein that in mammals is encoded by the FGF21 gene. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family and specifically a member of the "endocrine" subfamily which includes FGF23 and FGF15/19.

FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGFs act through a family of four FGF receptors. Binding is complicated and requires both interaction of the FGF molecule with an FGF receptor and binding to heparin through an heparin binding domain. Endocrine FGFs lack a heparin binding domain and thus can be released into the circulation. FGF21 action through one of the FGF21 receptors thus requires interaction with a co-receptor, designated β-klotho.

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