FGF18

FGF18
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4CJM
Identifiers
Aliases	FGF18, FGF-18, ZFGF5, fibroblast growth factor 18
External IDs	MGI: 1277980 HomoloGene: 2867 GeneCards: FGF18
Gene ontology Molecular function • fibroblast growth factor receptor binding • type 1 fibroblast growth factor receptor binding • type 2 fibroblast growth factor receptor binding • growth factor activity • protein tyrosine kinase activity • Ras guanyl-nucleotide exchange factor activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • 1-phosphatidylinositol-3-kinase activity Cellular component • extracellular region • nucleolus • extracellular space Biological process • intramembranous ossification • positive regulation of vascular endothelial growth factor receptor signaling pathway • regulation of sprouting angiogenesis • positive regulation of endothelial cell chemotaxis to fibroblast growth factor • positive regulation of MAP kinase activity • ossification • lung development • cell-cell signaling • anatomical structure morphogenesis • chondrocyte development • endochondral ossification • MAPK cascade • fibroblast growth factor receptor signaling pathway • positive regulation of chondrocyte differentiation • angiogenesis • positive regulation of cell proliferation • positive regulation of ERK1 and ERK2 cascade • regulation of endothelial cell proliferation • phosphatidylinositol-mediated signaling • signal transduction • positive regulation of GTPase activity • phosphatidylinositol phosphorylation • peptidyl-tyrosine phosphorylation • regulation of phosphatidylinositol 3-kinase signaling • phosphatidylinositol-3-phosphate biosynthetic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8817	14172
Ensembl	ENSG00000156427	ENSMUSG00000057967
UniProt	O76093	O89101
RefSeq (mRNA)	NM_033649 NM_003862	NM_008005
RefSeq (protein)	NP_003853	NP_032031.1 NP_032031
Location (UCSC)	Chr 5: 171.42 – 171.46 Mb	Chr 11: 33.12 – 33.15 Mb
PubMed search

4CJM

8817

14172

ENSG00000156427

ENSMUSG00000057967

O76093

O89101

NM_033649
NM_003862

NM_008005

NP_003853

NP_032031.1
NP_032031

Fibroblast growth factor 18 is a protein that in humans is encoded by the FGF18 gene.

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. FGF18 signals through fibroblast growth factor receptor FGFR3 to promote chondrogenesis and has been shown to cause thickening of cartilage in a murine model of osteoarthritis, and the recombinant version of it (sprifermin) will soon enter trials as a potential treatment for osteoarthritis. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures.

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