FDX1

FDX1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3N9Y, 3N9Z, 3NA0, 3NA1, 3P1M
Identifiers
Aliases	FDX1, ADX, FDX, LOH11CR1D, Adrenal ferredoxin, ferredoxin 1
External IDs	MGI: 103224 HomoloGene: 31216 GeneCards: FDX1
Gene ontology Molecular function • iron ion binding • electron carrier activity • iron-sulfur cluster binding • metal ion binding • 2 iron, 2 sulfur cluster binding Cellular component • mitochondrial matrix • mitochondrion Biological process • C21-steroid hormone biosynthetic process • sterol metabolic process • cholesterol metabolic process • oxidation-reduction process • small molecule metabolic process • hormone biosynthetic process • lipid metabolic process • steroid biosynthetic process • steroid metabolic process • cellular response to cAMP • cellular response to forskolin Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2230	14148
Ensembl	ENSG00000137714	ENSMUSG00000032051
UniProt	P10109	P46656
RefSeq (mRNA)	NM_004109	NM_001301728 NM_007996
RefSeq (protein)	NP_004100	NP_001288657 NP_032022
Location (UCSC)	Chr 11: 110.43 – 110.46 Mb	Chr 9: 51.94 – 51.96 Mb
PubMed search

3N9Y, 3N9Z, 3NA0, 3NA1, 3P1M

2230

14148

ENSG00000137714

ENSMUSG00000032051

P10109

P46656

NM_004109

NM_001301728
NM_007996

NP_004100

NP_001288657
NP_032022

Adrenal ferredoxin also known as adrenodoxin or adrenodoxin, mitochondrial or hepatoredoxin or ferredoxin-1 (FDX1) is a protein that in humans is encoded by the FDX1 gene. In addition to the expressed gene at this chromosomal locus (11q22), there are pseudogenes located on chromosomes 20 and 21.

Ferredoxin-1 is a small iron-sulfur protein that transfers electrons from NADPH through ferredoxin reductase to a terminal . This particular oxidation/reduction system is found in steroidogenic tissues, and is involved with the synthesis of bile acid and vitamin D. Ferredoxin-1 has been identified in a number of different tissues but all forms have been shown to be identical and are not tissue specific.

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Wikipedia