FBXO5

FBXO5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2M6N, 4UI9
Identifiers
Aliases	FBXO5, EMI1, FBX5, Fbxo31, F-box protein 5
External IDs	MGI: 1914391 HomoloGene: 8135 GeneCards: FBXO5
Gene ontology Molecular function • metal ion binding • protein binding • protein kinase binding Cellular component • cytoplasm • cytosol • spindle • nucleoplasm • cytoskeleton • nucleus Biological process • vesicle organization • G1/S transition of mitotic cell cycle • regulation of meiotic nuclear division • microtubule polymerization • regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • negative regulation of meiotic nuclear division • regulation of transcription involved in G1/S transition of mitotic cell cycle • cell division • spindle assembly • oocyte maturation • regulation of mitotic cell cycle • cell cycle • positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition • spindle assembly involved in female meiosis I • regulation of mitotic nuclear division • negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • positive regulation of ubiquitin protein ligase activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	26271	67141
Ensembl	ENSG00000112029	ENSMUSG00000019773
UniProt	Q9UKT4	Q7TSG3
RefSeq (mRNA)	NM_001142522 NM_012177	NM_025995
RefSeq (protein)	NP_001135994 NP_036309	NP_080271.2 NP_080271
Location (UCSC)	Chr 6: 152.97 – 152.98 Mb	Chr 10: 5.8 – 5.81 Mb
PubMed search

2M6N, 4UI9

26271

67141

ENSG00000112029

ENSMUSG00000019773

Q9UKT4

Q7TSG3

NM_001142522
NM_012177

NM_025995

NP_001135994
NP_036309

NP_080271.2
NP_080271

F-box only protein 5 is a protein that in humans is encoded by the FBXO5 gene.

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex.

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