FBLN5

Identifiers

FBLN5, ADCL2, ARCL1A, ARMD3, DANCE, EVEC, FIBL-5, UP50, HNARMD, fibulin 5

External IDs

MGI: 1346091 HomoloGene: 38170 GeneCards: FBLN5

Gene ontology
Molecular function	• protein C-terminus binding • calcium ion binding • protein homodimerization activity • protein binding • integrin binding
Cellular component	• extracellular region • extracellular exosome • extracellular matrix • elastic fiber • proteinaceous extracellular matrix • extracellular space
Biological process	• secretion • regulation of cell growth • regulation of removal of superoxide radicals • cell-matrix adhesion • extracellular matrix organization • protein localization to cell surface • cell adhesion • elastic fiber assembly
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


10516


23876

Ensembl


ENSG00000140092


ENSMUSG00000021186

UniProt


Q9UBX5


Q9WVH9

RefSeq (mRNA)


NM_006329


NM_011812

RefSeq (protein)


NP_006320


NP_035942.1 NP_035942

Location (UCSC)

Chr 14: 91.87 – 91.95 Mb

Chr 12: 101.75 – 101.82 Mb

PubMed search

NP_035942.1
NP_035942

Fibulin-5 is a protein that in humans is encoded by the FBLN5 gene.

The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling.

FBLN5 has been shown to interact with LOXL1.

FBLN5 mutations have been described in patients with age-related macular degeneration, as well as being involved in Charcot-Marie-Tooth neuropathies.

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Wikipedia