FAS ligand

FASLG
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4MSV
Identifiers
Aliases	FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6, TNLG1A, Fas ligand
External IDs	OMIM: 134638 MGI: 99255 HomoloGene: 533 GeneCards: FASLG
Gene ontology Molecular function • death receptor binding • cytokine activity • protein binding • tumor necrosis factor receptor binding • receptor binding Cellular component • integral component of membrane • membrane • cytoplasmic vesicle lumen • plasma membrane • integral component of plasma membrane • cell surface • lysosomal lumen • caveola • perinuclear region of cytoplasm • membrane raft • lysosome • extracellular exosome • cytoplasmic vesicle • nucleus • external side of plasma membrane • extracellular region • extracellular space Biological process • T cell apoptotic process • regulation of transcription, DNA-templated • activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway • cell-cell signaling • endosomal lumen acidification • negative regulation of transcription from RNA polymerase II promoter • retinal cell programmed cell death • transcription, DNA-templated • response to lipopolysaccharide • positive regulation of neuron apoptotic process • positive regulation of endothelial cell apoptotic process • necroptotic signaling pathway • immune response • positive regulation of cell proliferation • positive regulation of apoptotic process • positive regulation of I-kappaB kinase/NF-kappaB signaling • negative regulation of angiogenesis • regulation of extrinsic apoptotic signaling pathway via death domain receptors • cellular chloride ion homeostasis • response to growth factor • inflammatory cell apoptotic process • positive regulation of epidermal growth factor receptor signaling pathway • extrinsic apoptotic signaling pathway via death domain receptors • signal transduction • extrinsic apoptotic signaling pathway • activation of cysteine-type endopeptidase activity involved in apoptotic process • necroptotic process • apoptotic signaling pathway • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • apoptotic process • calcium ion transport from endoplasmic reticulum to cytosol Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	356	14103
Ensembl	ENSG00000117560	ENSMUSG00000000817
UniProt	P48023	P41047
RefSeq (mRNA)	NM_001302746 NM_000639	NM_001205243 NM_010177
RefSeq (protein)	NP_000630 NP_001289675	NP_034307.1 NP_001192172 NP_034307
Location (UCSC)	Chr 1: 172.66 – 172.67 Mb	Chr 1: 161.78 – 161.79 Mb
PubMed search

4MSV

356

14103

ENSG00000117560

ENSMUSG00000000817

P48023

P41047

NM_001302746
NM_000639

NM_001205243
NM_010177

NP_000630
NP_001289675

NP_034307.1
NP_001192172
NP_034307

Fas ligand (FasL or CD95L) is a type-II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. Its binding with its receptor induces apoptosis. Fas ligand/receptor interactions play an important role in the regulation of the immune system and the progression of cancer.

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Wikipedia