FAP (gene)

FAP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Z68
Identifiers
Aliases	FAP, DPPIV, FAPA, SIMP, fibroblast activation protein alpha
External IDs	MGI: 109608 HomoloGene: 48282 GeneCards: FAP
EC number	3.4.14.5
Gene ontology Molecular function • protein dimerization activity • protein homodimerization activity • endopeptidase activity • protease binding • integrin binding • peptidase activity • protein binding • serine-type peptidase activity • metalloendopeptidase activity • serine-type endopeptidase activity • hydrolase activity • dipeptidyl-peptidase activity Cellular component • cytoplasm • integral component of membrane • cell projection • membrane • focal adhesion • invadopodium membrane • basal part of cell • plasma membrane • apical part of cell • ruffle membrane • extracellular region • cell surface • cell junction • lamellipodium membrane • lamellipodium • extracellular space Biological process • mitotic cell cycle arrest • positive regulation of execution phase of apoptosis • regulation of collagen catabolic process • melanocyte apoptotic process • negative regulation of extracellular matrix disassembly • negative regulation of extracellular matrix organization • proteolysis • cell adhesion • negative regulation of cell proliferation involved in contact inhibition • angiogenesis • melanocyte proliferation • proteolysis involved in cellular protein catabolic process • regulation of fibrinolysis • endothelial cell migration • positive regulation of cell cycle arrest • apoptotic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2191	14089
Ensembl	ENSG00000078098	ENSMUSG00000000392
UniProt	Q12884	P97321
RefSeq (mRNA)	NM_001291807 NM_004460	NM_007986
RefSeq (protein)	NP_001278736 NP_004451	NP_032012.1 NP_032012
Location (UCSC)	Chr 2: 162.17 – 162.25 Mb	Chr 2: 62.5 – 62.57 Mb
PubMed search

1Z68

2191

14089

ENSG00000078098

ENSMUSG00000000392

Q12884

P97321

NM_001291807
NM_004460

NM_007986

NP_001278736
NP_004451

NP_032012.1
NP_032012

Fibroblast activation protein alpha is a 170 kDa melanoma membrane-bound gelatinase, protein that in humans is encoded by the FAP gene.

The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis.

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Wikipedia