F11R

F11R
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1NBQ, 3EOY, 3TSZ, 4ODB
Identifiers
Aliases	F11R, F11r, 9130004G24, AA638916, ESTM33, JAM, JAM-1, JAM-A, Jcam, Jcam1, Ly106, CD321, JAM1, JAMA, KAT, PAM-1, F11 receptor
External IDs	MGI: 1321398 HomoloGene: 14255 GeneCards: F11R
Gene location (Human) Chr. Chromosome 1 (human) Band 1q23.3 Start 160,995,211 bp End 161,021,348 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1 H3|1 79.43 cM Start 171,437,535 bp End 171,464,603 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • PDZ domain binding • virus receptor activity • protein binding • cadherin binding Cellular component • integral component of membrane • membrane • cell-cell junction • bicellular tight junction • plasma membrane • slit diaphragm • extracellular exosome • cytoplasmic vesicle • cell junction Biological process • regulation of actin cytoskeleton reorganization • cell differentiation • establishment of endothelial intestinal barrier • epithelial cell differentiation • actomyosin structure organization • extracellular matrix organization • regulation of membrane permeability • regulation of cytokine production • positive regulation of GTPase activity • positive regulation of blood pressure • cell adhesion • negative regulation of GTPase activity • bicellular tight junction assembly • viral entry into host cell • intestinal absorption • response to radiation • inflammatory response • viral process • transforming growth factor beta receptor signaling pathway • leukocyte migration • protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	50848	16456
Ensembl	ENSG00000158769	ENSMUSG00000038235
UniProt	Q9Y624	O88792
RefSeq (mRNA)	NM_016946 NM_144501 NM_144502 NM_144503 NM_144504 NM_001348091	NM_172647
RefSeq (protein)	NP_058642 NP_001335020	NP_766235
Location (UCSC)	Chr 1: 161 – 161.02 Mb	Chr 1: 171.44 – 171.46 Mb
PubMed search

1NBQ, 3EOY, 3TSZ, 4ODB

50848

16456

ENSG00000158769

ENSMUSG00000038235

Q9Y624

O88792

NM_001348091

NM_172647

NP_058642
NP_001335020

NP_766235

Junctional adhesion molecule A is a protein that in humans is encoded by the F11R gene. It has also been designated as CD321 (cluster of differentiation 321).

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple transcript variants encoding two different isoforms have been found for this gene.

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