The Departure from the walls in Jerusalem was the process of building new residences outside of the Old City walls, and shifting the city center to the new neighborhoods. The process started in the mid-19th century and by the early 20th century had entirely transformed the city.
In the mid 19th century, with an area of only one square kilometer, the Old City had become overcrowded and unsanitary, and rental prices were increasingly rising. In the mid-1850s, following the Crimean War, institutions including the Russian Compound, Kerem Avraham, the Schneller Orphanage, Bishop Gobat school and the Mishkenot Sha'ananim, marked the beginning of permanent settlement outside the Jerusalem Old City walls.
In 1855, Johann Ludwig Schneller, a Lutheran missionary who came to Jerusalem at the age of 34, bought a plot of land outside the Old City walls when the area was a complete wilderness. He built a house there but was forced to move his family back inside the walls after several attacks by marauders. When the Turks erected outposts along Jaffa Road, between Jerusalem and the port city of Jaffa, and armed guards on horseback patrolled the road, the family returned.
The public institutions were followed by the development of two philanthropically supported Jewish neighborhoods, Mishkenot Sha’ananim and Mahane Israel.
Mishkenot Sha’ananim (Hebrew: משכנות שאננים) was the first Jewish neighborhood built outside the walls of the Old City of Jerusalem, on a hill directly across from Mount Zion. It was built by Sir Moses Montefiore in 1860 as an almshouse, paid for by the estate of a wealthy Jew from New Orleans, Judah Touro. Since it was outside the walls and open to Bedouin raids, pillage and general banditry rampant in the region at the time, the Jews were reluctant to move in, even though the housing was luxurious compared to the derelict and overcrowded houses in the Old City. As an incentive, people were paid to live there, and a wall was built around the compound with a heavy door that was locked at night. The name of the neighborhood was taken from the Book of Isaiah 32:18: "My people will abide in peaceful habitation, in secure dwellings and in quiet resting places."