"Everything Starts with an 'E'" is a song by E-Zee Possee featuring vocals from MC Kinky. It is considered by many to be the anthem of the acid house movement of the late 1980s, with the "E" in the title widely understood to refer to the drug Ecstasy (MDMA).

The song began life as an instrumental interpretation of Jeremy Healy and Simon Rogers' idea of house music after a trip to Ibiza which upon being presented to Boy George had vocals added to it by MC Kinky, Boy George and Eve Gallagher. This vocal version charted #15 on the UK Singles Chart, and although a music video was created for it, no-one played it due to its offensive lyrical content. Retrospective critical reception for the song was scathing.

E-Zee-Possee was a group compiled by Jeremy Healy of Haysi Fantayzee fame. It uses a different vocalist for each record owing to his experiences producing the Business Mix of Boy George's "Live My Life" with extra vocals with street rapper MC Cyndee.

"Everything Starts with an 'E'" was initially produced as an instrumental dance record with assorted samples by Jimi Hendrix, Lost in Space and from classical music. It was written by Healy immediately after his first trip to Ibiza, where the acid house movement was in full swing, as Healy's and Rogers' interpretation of house music at the time having taken heavy inspiration from the music being played there. The title, "Everything Starts with an 'E'", originated from a Ronald McDonald LP which contained the line and was subsequently sampled in the song. Healy then presented it to Boy George, who suggested they use MC Kinky, a white female raggamuffin toaster who had previously featured on his song Kipsy. She then used the song to write what according to her was an anti-drug rant. Boy George and Eve Gallagher both provide backing vocals for the record. It was rejected by every label George went to and eventually he opted to front the money himself, pressing a thousand copies with the intent to get it played in the clubs. Its first play was in the Hacienda in Manchester, and after becoming a theme for many of the raves, Virgin Records surrendered and signed the band. Although BBC Radio 1 initially banned the song due to perceived offensive lyrical content, it was performed on the Sky1 show Hits International, and would later chart at #15 on the UK Singles Chart, remaining the flagship for George's More Protein label as well as an anthem for the entire acid house movement of the late 1980s. It later appeared on E-Zee Possee's album The Bone Dance alongside follow-up singles "Love On Love", "The Sun Machine" and "Breathing Is E-Zee" as well as on Now That's What I Call Music! 17. After the earlier ban, the song was played on BBC stations at various times in 2010 and later.

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