Eukaryotic translation initiation factor 4 gamma

EIF4G1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1LJ2, 1UG3, 2W97, 4AZA, 4F02

Identifiers

Aliases

EIF4G1, EIF-4G1, EIF4F, EIF4G, EIF4GI, P220, PARK18, Eukaryotic translation initiation factor 4 gamma, eukaryotic translation initiation factor 4 gamma 1

External IDs

MGI: 2384784 HomoloGene: 110725 GeneCards: EIF4G1

Gene ontology
Molecular function	• translation initiation factor activity • protein binding • RNA binding • mRNA binding • ATP binding • translation factor activity, RNA binding • eukaryotic initiation factor 4E binding • translation initiation factor binding • protein complex scaffold • cadherin binding
Cellular component	• cytosol • membrane • nucleus • cytoplasm • polysome • eukaryotic translation initiation factor 4F complex • cytosolic small ribosomal subunit
Biological process	• nuclear-transcribed mRNA poly(A) tail shortening • regulation of mRNA stability • behavioral fear response • positive regulation of neuron differentiation • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • viral process • regulation of translation • regulation of translational initiation • cap-dependent translational initiation • translation • translational initiation • mitochondrion organization • positive regulation of cell proliferation • negative regulation of autophagy • negative regulation of peptidyl-threonine phosphorylation • positive regulation of cell growth • positive regulation of cellular protein metabolic process • developmental process • positive regulation of peptidyl-serine phosphorylation • cellular macromolecule biosynthetic process • regulation of gene silencing by miRNA • regulation of cellular response to stress • positive regulation of G1/S transition of mitotic cell cycle • negative regulation of neuron death • positive regulation of eukaryotic translation initiation factor 4F complex assembly • regulation of presynapse assembly • positive regulation of mRNA cap binding • positive regulation of miRNA mediated inhibition of translation • regulation of polysome binding • positive regulation of energy homeostasis
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


1981


208643

Ensembl


ENSG00000114867


ENSMUSG00000045983

UniProt


Q04637


Q6NZJ6

RefSeq (mRNA)

NM_198244 NM_001194946 NM_001194947 NM_001291157 NM_004953
NM_182917 NM_198241 NM_198242


NM_001005331 NM_145941 NM_001304432

RefSeq (protein)

NP_001181875 NP_001181876 NP_001278086 NP_004944 NP_886553
NP_937884 NP_937885 NP_937887


NP_001291361.1 NP_666053.2 NP_001291361 NP_666053

Location (UCSC)

Chr 3: 184.31 – 184.34 Mb

Chr 16: 20.67 – 20.69 Mb

PubMed search

1LJ2, 1UG3, 2W97, 4AZA, 4F02

NM_182917
NM_198241
NM_198242

NM_001005331
NM_145941
NM_001304432

NP_937884
NP_937885
NP_937887

NP_001291361.1
NP_666053.2
NP_001291361
NP_666053

...
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