Eugene George Istomin (November 26, 1925 – October 10, 2003) was an American pianist. He was famous for his work in a piano trio in which he collaborated with Isaac Stern and Leonard Rose.
Born in New York City of Russian parents, Istomin was a child prodigy. His earliest public performances began at age six with his mother, and at 12 he entered the Curtis Institute, having had earlier advice from Alexander Siloti and his daughter Kyriena. He went on to study under Rudolf Serkin and also Mieczysław Horszowski.
In 1943, at the age of 17, he won the Leventritt award and the Philadelphia Youth Award. He made his debut with the Philadelphia Orchestra with Eugene Ormandy, playing a concerto by Chopin, and the New York Philharmonic conducted by Artur Rodziński playing Brahms' Piano Concerto No. 2 in the same week in 1943.
He performed with the conductor Rodzinski and the New York Philharmonic a second time in December 1944, playing Beethoven's Fourth Piano Concerto.
He commissioned and premiered Roger Sessions' piano concerto in 1956. Several other composers, including Henri Dutilleux and Ned Rorem, wrote music for him.