Estropipate

Estropipate
Clinical data

AHFS/Drugs.com	Monograph
ATC code	none
Identifiers
IUPAC name [(8R,9S,13S,14S)-13-Methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl] hydrogen sulfate; piperazine
CAS Number	7280-37-7^N
PubChem CID	5284555
DrugBank	DB04574^Y
ChemSpider	4447610^Y
UNII	SVI38UY019
KEGG	D00948^Y
ChEMBL	CHEMBL1200980^N
ECHA InfoCard	100.027.906
Chemical and physical data
Formula	C₂₂H₃₂N₂O₅S
Molar mass	436.56 g/mol
3D model (Jmol)	Interactive image
SMILES O=S(=O)(O)Oc1cc4c(cc1)[C@@H]3[C@H]([C@@H]2CCC(=O)[C@@]2(C)CC3)CC4.N1CCNCC1
InChI InChI=1S/C18H22O5S.C4H10N2/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;1-2-6-4-3-5-1/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22);5-6H,1-4H2/t14-,15-,16+,18+;/m1./s1^Y Key:HZEQBCVBILBTEP-ZFINNJDLSA-N^Y
^NY (what is this?)

Estropipate (INN, USAN, BAN) (brand names Harmogen, Improvera, Ogen, Ortho-Est, many others), also known as piperazine estrone sulfate, is a semi-synthetic, steroidal estrogen that is used mainly in hormone replacement therapy in the treatment of symptoms of menopause. It is a salt of estrone sulfate and piperazine, and is hydrolyzed into estrone in the body.

Estropipate is used to:

Estropipate is an agonist of the estrogen receptor (ER). In addition, estropipate has been found to act as an inhibitor of SLCO1B1 (OATP1B1) (IC₅₀ = 70 nM).[1]